Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE009517-12
Application #
6516442
Study Section
Oral Biology and Medicine Subcommittee 1 (OBM)
Program Officer
Lunsford, Dwayne
Project Start
1990-07-01
Project End
2006-03-31
Budget Start
2002-04-01
Budget End
2003-03-31
Support Year
12
Fiscal Year
2002
Total Cost
$301,150
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Pathology
Type
Schools of Dentistry
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Kaplan, J B; Sampathkumar, V; Bendaoud, M et al. (2017) In vitro characterization of biofilms formed by Kingella kingae. Mol Oral Microbiol 32:341-353
Brown, A C; Koufos, E; Balashova, N V et al. (2016) Inhibition of LtxA toxicity by blocking cholesterol binding with peptides. Mol Oral Microbiol 31:94-105
Shahabuddin, Nishat; Boesze-Battaglia, Kathleen; Lally, Edward T (2016) Trends in Susceptibility to Aggressive Periodontal Disease. Int J Dent Oral Health 2:
Balashova, N; Dhingra, A; Boesze-Battaglia, K et al. (2016) Aggregatibacter actinomycetemcomitans leukotoxin induces cytosol acidification in LFA-1 expressing immune cells. Mol Oral Microbiol 31:106-14
Bárcena-Uribarri, Iván; Benz, Roland; Winterhalter, Mathias et al. (2015) Pore forming activity of the potent RTX-toxin produced by pediatric pathogen Kingella kingae: Characterization and comparison to other RTX-family members. Biochim Biophys Acta 1848:1536-44
Brown, Angela C; Balashova, Nataliya V; Epand, Richard M et al. (2013) Aggregatibacter actinomycetemcomitans leukotoxin utilizes a cholesterol recognition/amino acid consensus site for membrane association. J Biol Chem 288:23607-21
Walters, M J; Brown, A C; Edrington, T C et al. (2013) Membrane association and destabilization by Aggregatibacter actinomycetemcomitans leukotoxin requires changes in secondary structures. Mol Oral Microbiol 28:342-53
Brown, Angela C; Boesze-Battaglia, Kathleen; Du, Yurong et al. (2012) Aggregatibacter actinomycetemcomitans leukotoxin cytotoxicity occurs through bilayer destabilization. Cell Microbiol 14:869-81
Fong, K P; Tang, H-Y; Brown, A C et al. (2011) Aggregatibacter actinomycetemcomitans leukotoxin is post-translationally modified by addition of either saturated or hydroxylated fatty acyl chains. Mol Oral Microbiol 26:262-76
Kieba, Irene R; Fong, Karen P; Tang, Hsin-Yao et al. (2007) Aggregatibacter actinomycetemcomitans leukotoxin requires beta-sheets 1 and 2 of the human CD11a beta-propeller for cytotoxicity. Cell Microbiol 9:2689-99

Showing the most recent 10 out of 32 publications