Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE011367-04
Application #
2132642
Study Section
Special Emphasis Panel (ZDE1-YS (33))
Project Start
1994-09-30
Project End
1998-09-29
Budget Start
1996-09-30
Budget End
1997-09-29
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Seattle Biomedical Research Institute
Department
Type
DUNS #
City
Seattle
State
WA
Country
United States
Zip Code
98109
Bhattacharya, Somanon; Esquivel, Brooke D; White, Theodore C (2018) Overexpression or Deletion of Ergosterol Biosynthesis Genes Alters Doubling Time, Response to Stress Agents, and Drug Susceptibility in Saccharomyces cerevisiae. MBio 9:
Esquivel, Brooke D; Smith, Adam R; Zavrel, Martin et al. (2015) Azole drug import into the pathogenic fungus Aspergillus fumigatus. Antimicrob Agents Chemother 59:3390-8
Zavrel, Martin; White, Theodore C (2015) Medically important fungi respond to azole drugs: an update. Future Microbiol 10:1355-73
Zavrel, Martin; Hoot, Sam J; White, Theodore C (2013) Comparison of sterol import under aerobic and anaerobic conditions in three fungal species, Candida albicans, Candida glabrata, and Saccharomyces cerevisiae. Eukaryot Cell 12:725-38
Brown, Gordon D; Denning, David W; Gow, Neil A R et al. (2012) Hidden killers: human fungal infections. Sci Transl Med 4:165rv13
Hoot, Samantha J; Smith, Adam R; Brown, Ryan P et al. (2011) An A643V amino acid substitution in Upc2p contributes to azole resistance in well-characterized clinical isolates of Candida albicans. Antimicrob Agents Chemother 55:940-2
Hoot, Samantha J; Brown, Ryan P; Oliver, Brian G et al. (2010) The UPC2 promoter in Candida albicans contains two cis-acting elements that bind directly to Upc2p, resulting in transcriptional autoregulation. Eukaryot Cell 9:1354-62
Mansfield, Bryce E; Oltean, Hanna N; Oliver, Brian G et al. (2010) Azole drugs are imported by facilitated diffusion in Candida albicans and other pathogenic fungi. PLoS Pathog 6:e1001126
Marie, Chelsea; White, Theodore C (2009) Genetic Basis of Antifungal Drug Resistance. Curr Fungal Infect Rep 3:163-169
Richards, Theresa S; Oliver, Brian G; White, Theodore C (2008) Micafungin activity against Candida albicans with diverse azole resistance phenotypes. J Antimicrob Chemother 62:349-55

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