Hemifacial microsomia (HFM), the second most common craniofacial malformation, has significant functional and cosmetic consequences. While experimental evidence suggests a vascular etiology, there have been no published epidemiologic studies of risk factors for HFM, and its causes remain largely unknown. The proposed project is a continuation of a multicenter case-control study of HFM in relation to 1) maternal exposure to decongestants; 2) maternal exposure to other vasoactive agents, such as alcohol, coffee, cigarette smoking, aspirin, and ibuprofen; 3) maternal exposure to other environmental risk factors, such as other medications, illnesses, and nutritional factors; and 4) possible gene/environment interactions. We propose an additional aim: 5) to examine HFM risk in relation to the combination of decongestant and cigarette use. Cases will be identified at tertiary care institutions in 26 metropolitan areas in the U.S. and Canada. Controls will be identified by the case infant's primary physician (pediatrician or family doctor) and will comprise the next three infants born after the case. Mothers of cases and controls will be interviewed within three months after the date of case ascertainment by telephone. The standardized questionnaire inquires in detail about demographic factors; reproductive, medical and pregnancy illness histories; medication use; behaviors (smoking, alcohol, coffee); and nutrition. Before the interview, each mother will be sent a medication identification booklet which includes color pictures of over 200 over-the-counter cough/cold and analgesic products to help recall of medications used during early pregnancy. A separate component of the study will be collection of buccal cell samples from the study infant, and his/her mother and father. Standardized photographs will be taken and the medical record of each case infant will be reviewed for HFM classification. The original study expected to include 275 cases and 825 controls (3 controls per case) within 38 months of data collection. Ascertainment of cases has been lower than originally projected, with 77 percent of 275 (or 213) cases to be included by the end of data collection phase of the study. Continuation of the project for an additional 18 months will allow an additional 63 cases and 228 controls to be included. Thus, the original target number of cases and controls will be met.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE011939-06
Application #
6516487
Study Section
Special Emphasis Panel (ZRG1-SNEM-2 (03))
Program Officer
Riddle, Melissa
Project Start
1997-07-01
Project End
2003-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
6
Fiscal Year
2002
Total Cost
$228,250
Indirect Cost
Name
Boston University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Speltz, Matthew L; Wallace, Erin R; Collett, Brent R et al. (2017) Intelligence and Academic Achievement of Adolescents with Craniofacial Microsomia. Plast Reconstr Surg 140:571-580
Parker, Samantha E; Lijewski, Virginia A; Janulewicz, Patricia A et al. (2016) Upper respiratory infection during pregnancy and neurodevelopmental outcomes among offspring. Neurotoxicol Teratol 57:54-59
Parker, S E; Collett, B R; Speltz, M L et al. (2016) Prenatal smoking and childhood behavior problems: is the association mediated by birth weight? J Dev Orig Health Dis :1-9
Parker, Samantha E; Starr, Jacqueline R; Collett, Brent R et al. (2014) Nausea and vomiting during pregnancy and neurodevelopmental outcomes in offspring. Paediatr Perinat Epidemiol 28:527-35
Khetani, Mary A; Collett, Brent R; Speltz, Matthew L et al. (2013) Health-related quality of life in children with hemifacial microsomia: parent and child perspectives. J Dev Behav Pediatr 34:661-8
Stone, Sarah Lederberg; Speltz, Matthew L; Collett, Brent et al. (2013) Socioeconomic Factors in Relation to Discrepancy in Parent versus Teacher Ratings of Child Behavior. J Psychopathol Behav Assess 35:314-320
Collett, Brent R; Speltz, Matthew L; Cloonan, Yona Keich et al. (2011) Neurodevelopmental outcomes in children with hemifacial microsomia. Arch Pediatr Adolesc Med 165:134-40
Dufton, Lynette M; Speltz, Matthew L; Kelly, Judith P et al. (2011) Psychosocial outcomes in children with hemifacial microsomia. J Pediatr Psychol 36:794-805
Li, Lin; Werler, Martha M (2010) Fruit and vegetable intake and risk of upper respiratory tract infection in pregnant women. Public Health Nutr 13:276-82
Cloonan, Yona K; Kifle, Yemiserach; Davis, Scott et al. (2009) Sleep outcomes in children with hemifacial microsomia and controls: a follow-up study. Pediatrics 124:e313-21

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