Amorphous calcium phosphate (ACP), a key precursor in the biological formation of hydroxyapatite (HAP), has received less attention as a dental material than crystalline calcium phosphates (CaPs). ACP, however, has two properties that justify its utilization as a possible remineralizing agent: it is one of the most soluble of all the biologically important CaPs, and it exhibits the most rapid conversion to HAP. Recently we developed unique polymeric dental composites/sealants that utilized these properties of ACP to remineralize bovine enamel lesions in vitro. However, as currently formulated, these ACP composites have relatively low mechanical strength and adhesiveness to teeth. Such shortcomings may limit their wider utilization in dentistry. The objectives of this proposal are (1) to develop effective remineralizing dental composites based on ACP that will have optimal mechanical and adhesive properties while maintaining sustained release of Ca and PO4 ions, and (2) to enhance our understanding of the remineralizing behavior of these ACP-based materials, especially the major factors that control Ca and PO4 ion release and redeposition into HAP. To accomplish these objectives we propose to: l] prepare ACP fillers with structurally incorporated silica, zirconia, and/or titania; 2] develop surface- modified hybrid ACP fillers amenable to treatment by silane coupling agents; 3] explore the effects of resin composition on the, mechanical and physicochemical properties of ACP-composites, and 4] evaluate the effects of bifunctional methacrylates on the adhesion of the composites to tooth substrates. It is expected that this research will both advance our fimdamenta1 understanding of these novel bioactive composites and eventually lead to clinically useful products. The extended, time-releasing nature of these ACP based polymeric materials should be especially useful in dental sealant and adhesive applications for preventing demineralization or promoting remineralization.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE013169-03
Application #
6516549
Study Section
Special Emphasis Panel (ZRG1-OBM-1 (02))
Program Officer
Wan, Jason
Project Start
2000-03-01
Project End
2004-02-29
Budget Start
2002-03-01
Budget End
2003-02-28
Support Year
3
Fiscal Year
2002
Total Cost
$141,546
Indirect Cost
Name
American Dental Association Foundation
Department
Type
DUNS #
789085941
City
Chicago
State
IL
Country
United States
Zip Code
60611
Bienek, Diane R; Tutak, Wojtek; Skrtic, Drago (2017) Bioactive Polymeric Materials for Tissue Repair. J Funct Biomater 8:
Skrtic, Drago; Antonucci, Joseph M (2016) Polymeric dental composites based on remineralizing amorphous calcium phosphate fillers. Curr Trends Polym Sci 17:1-31
Marovi?, Danijela; Ĺ ariri, Kristina; Demoli, Nazif et al. (2016) Remineralizing amorphous calcium phosphate based composite resins: the influence of inert fillers on monomer conversion, polymerization shrinkage, and microhardness. Croat Med J 57:465-473
Marovic, Danijela; Tarle, Zrinka; Hiller, Karl Anton et al. (2014) Effect of silanized nanosilica addition on remineralizing and mechanical properties of experimental composite materials with amorphous calcium phosphate. Clin Oral Investig 18:783-92
Zhang, Fan; Allen, Andrew J; Levine, Lyle E et al. (2014) Structural and dynamical studies of acid-mediated conversion in amorphous-calcium-phosphate based dental composites. Dent Mater 30:1113-25
Zhang, Fan; Allen, Andrew J; Levine, Lyle E et al. (2012) Ultra-small-angle X-ray scattering-X-ray photon correlation spectroscopy studies of incipient structural changes in amorphous calcium phosphate-based dental composites. J Biomed Mater Res A 100:1293-306
Antonucci, J M; Skrtic, D (2011) PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES OF REMINERALIZING, POLYMERIC ACP COMPOSITES. Polymer Prepr 52:183-184
Skrtic, Drago; Antonucci, Joseph M (2011) Bioactive polymeric composites for tooth mineral regeneration: physicochemical and cellular aspects. J Funct Biomater 2:271-307
Antonucci, J M; Davis, C H; Sun, J et al. (2011) Leachability and Cytotoxicity of an Experimental Polymeric ACP Composite. PMSE Preprints 104:300-302
Antonucci, J M; Skrtic, D (2010) Physicochemical Evaluation of an Experimental Endodontic Sealer. Polymer Prepr 51:173-174

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