This application is in response to NOT-OD-09-058, titled """"""""NIH announces the availability of Recovery Act Funds for Competitive Revision Applications"""""""". The goal of this application, which is related to an NIDCR R01 grant (DE13814) titled """"""""Functional Outcomes of Cleft Lip Surgery"""""""", is to extend the analysis of facial function (movement) and form to babies (<6 months) born with a cleft lip. Presently, surgical results after an initial or primary lip repair are highly variable. Many patients require additional lip 'revision'surgeries. In the parent grant, approaches were developed to objectively determine patient-specific impairment and disfigurement of the circumoral region for after revision surgeries in patients 5 to 21 years of age. It would be of great value to surgeons to know the functional capability of the circumoral region before the initial surgical repair of the cleft defect so that they may be better informed about the biological effects of the repair, and as a result, gain information to improve the surgical outcome and limit the need for additional surgeries. We will explore the use of novel measures developed in the parent grant for the assessment of facial soft tissue functional characteristics in a group of cleft babies followed longitudinally and tested before and after primary lip surgery. A second group of age-matched, non-cleft babies will serve as controls and will be tested at similar time points.
The Specific Aims of the application are as follows. 1) To collect 3D dynamic and static facial images from a group of babies born with a cleft lip (with or without a cleft palate) before and after primary lip repair;and from a group of age- and sex-matched non-cleft control babies. 2) To develop and refine objective measures of facial function and form that will be applicable for babies with facial disability;and 3) To explore the use of preliminary analyses to determine differences in facial function and form between babies with and without a cleft lip;and for those babies with a cleft lip, before and after primary lip repair.
The esthetic results after an initial or primary lip repair in patients with a cleft lip tend to be highly variable. Many patients remain with an obvious facial disability, and may require additional 'revision'surgeries. In the parent grant, we developed methods and analyses to objectively quantify facial form and movement characteristics in patients 5 to 21 years of age. The intent of this application is to apply our methods and explore analyses to assess dynamic facial movements and static facial form that are present in babies at an early age of 6 months, and to determine how the form is affected and whether the facial movement is still apparent after the primary lip surgery. Such information can help determine how early in age longitudinal observations need to be obtained for a comparison of treatment intervention methods.
| Chu, Shin Ying; Barlow, Steven M; Lee, Jaehoon (2015) Face-referenced measurement of perioral stiffness and speech kinematics in Parkinson's disease. J Speech Lang Hear Res 58:201-12 |
| Mercado, A M; Phillips, C; Vig, K W L et al. (2014) The effects of lip revision surgery on nasolabial esthetics in patients with cleft lip. Orthod Craniofac Res 17:216-25 |
| Trotman, Carroll-Ann; Phillips, Ceib; Faraway, Julian J et al. (2013) Influence of objective three-dimensional measures and movement images on surgeon treatment planning for lip revision surgery. Cleft Palate Craniofac J 50:684-95 |
| Trotman, Carroll-Ann E; Faraway, Julian; Soltmann, Renate et al. (2013) Facial soft tissue dynamics before and after primary lip repair. Cleft Palate Craniofac J 50:315-22 |
| Essick, Greg; Phillips, Ceib; Chung, Yunro et al. (2013) Effects of lip revision surgery on long-term orosensory function in patients with cleft lip/palate. Cleft Palate Craniofac J 50:507-12 |
| Liu, Jun; Zhou, Hongzhi; Weir, Michael D et al. (2012) Fast-degradable microbeads encapsulating human umbilical cord stem cells in alginate for muscle tissue engineering. Tissue Eng Part A 18:2303-14 |
| Barlow, Steven M; Trotman, Carroll-Ann; Chu, Shin-Ying et al. (2012) Modification of perioral stiffness in patients with repaired cleft lip and palate. Cleft Palate Craniofac J 49:524-9 |
| Faraway, Julian J; Trotman, Carroll-Ann (2011) Shape change along geodesics with application to cleft lip surgery. J R Stat Soc Ser C Appl Stat 60:743-755 |
| Trotman, Carroll-Ann (2011) Faces in 4 dimensions: Why do we care, and why the fourth dimension? Am J Orthod Dentofacial Orthop 140:895-9 |
| Trotman, C-A; Faraway, J J; Phillips, C et al. (2010) Effects of lip revision surgery in cleft lip/palate patients. J Dent Res 89:728-32 |
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