The overall objective of this proposed research is to develop near-infrared imaging for the detection and diagnosis of early dental caries (dental decay). New, more sophisticated diagnostic tools are needed for the detection and characterization of caries lesions in the early stages of development. If carious lesions are detected early enough, before cavitation, then they can be arrested/remineralized by non-surgical means through fluoride therapy, anti-bacterial therapy, dietary changes, or by low intensity laser irradiation. The principal factor limiting optical transmission through the tooth i the visible range from 400-700-nm is light scattering in sound enamel and dentin. The magnitude of light scattering decreases markedly at longer wavelengths in the near infrared due to the size of the principal light scatterers in enamel. The central hypothesis of this proposal is that the near-IR (NIR) region between 1300 and 1700-nm offers the greatest potential for new optical imaging modalities due to the weak scattering and absorption in sound dental hard tissue. The overall objectives of this proposal will be achieved through the following specific aims: (1) To test the hypothesis that the maximum contrast between sound and demineralized enamel in NIR reflectance measurements lies in the wavelength regions coincident with weak light scattering in enamel and strong water absorption, (2) To test the hypothesis that NIR imaging on proximal and occlusal surfaces can used for improved assessment of caries lesions for clinical screening, (3) To test the hypothesis that a NIR imaging system can be used for improved discrimination of composite sealants and restorations from sound and demineralized tooth structure. It is likely that if these studies and future clinical trials are a success, that his novel technology for imaging dental hard tissue will be employed for the detection and monitoring of early carious lesions without the use of ionizing radiation, thereby enabling conservative non-surgical intervention and the preservation of healthy tissue structure.
This proposed research is relevant to public health because the development of new improved imaging methods for the detection and monitoring of early carious lesions is expected to enable conservative non- surgical intervention with preservation of healthy tissue structure without the use of ionizing radiation. The proposed research is relevant to the mission of the NIDCR because it pertains to the development of new diagnostic tools for the detection and characterization of caries lesions in the early stages of development.
|Chang, Nai-Yuan N; Jew, Jamison M; Fried, Daniel (2018) Lesion Dehydration Rate Changes with the Surface Layer Thickness during Enamel Remineralization. Proc SPIE Int Soc Opt Eng 10473:|
|Chan, Kenneth H; Fried, Daniel (2018) Multispectral cross-polarization reflectance measurements suggest high contrast of demineralization on tooth surfaces at wavelengths beyond 1300 nm due to reduced light scattering in sound enamel. J Biomed Opt 23:1-4|
|Simon, Jacob C; Curtis, Donald A; Darling, Cynthia L et al. (2018) Multispectral near-infrared reflectance and transillumination imaging of occlusal carious lesions: Variation in lesion contrast with lesion depth. Proc SPIE Int Soc Opt Eng 10473:|
|Chang, Nai-Yuan N; Jew, Jamison; Simon, Jacob C et al. (2017) Influence of Multi-Wavelength Laser Irradiation of Enamel and Dentin Surfaces on Surface Morphology and Permeability. Proc SPIE Int Soc Opt Eng 10044:|
|Simon, Jacob C; Darling, Cynthia L; Fried, Daniel (2017) Assessment of cavitation in artificial approximal dental lesions with near-IR imaging. Proc SPIE Int Soc Opt Eng 10044:|
|Lee, Robert C; Darling, Cynthia L; Staninec, Michal et al. (2017) Activity assessment of root caries lesions with thermal and near-IR imaging methods. J Biophotonics 10:433-445|
|Chan, Kenneth H; Fried, Daniel (2017) Selective Laser Ablation of Carious Lesions using Simultaneous Scanned Near-IR Diode and CO2 Lasers. Proc SPIE Int Soc Opt Eng 10044:|
|Berg, Rhett A; Simon, Jacob C; Fried, Daniel et al. (2017) Optical changes of dentin in the near-IR as a function of mineral content. Proc SPIE Int Soc Opt Eng 10044:|
|Simon, Jacob C; Kang, Hobin; Staninec, Michal et al. (2017) Near-IR and CP-OCT imaging of suspected occlusal caries lesions. Lasers Surg Med 49:215-224|
|Chang, Nai-Yuan N; Jew, Jamison M; Simon, Jacob C et al. (2017) Influence of multi-wavelength laser irradiation of enamel and dentin surfaces at 0.355, 2.94, and 9.4??m on surface morphology, permeability, and acid resistance. Lasers Surg Med 49:913-927|
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