Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK015056-26
Application #
2136883
Study Section
Metallobiochemistry Study Section (BMT)
Project Start
1979-02-01
Project End
1998-01-31
Budget Start
1996-04-05
Budget End
1997-01-31
Support Year
26
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Physiology
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
Ikuta, Katsuya; Yersin, Alexandre; Ikai, Atsushi et al. (2010) Characterization of the interaction between diferric transferrin and transferrin receptor 2 by functional assays and atomic force microscopy. J Mol Biol 397:375-84
Dhungana, Suraj; Taboy, Celine H; Zak, Olga et al. (2004) Redox properties of human transferrin bound to its receptor. Biochemistry 43:205-9
Ikuta, Katsuya; Zak, Olga; Aisen, Philip (2004) Recycling, degradation and sensitivity to the synergistic anion of transferrin in the receptor-independent route of iron uptake by human hepatoma (HuH-7) cells. Int J Biochem Cell Biol 36:340-52
Nosanchuk, Joshua D; van Duin, David; Mandal, Piyali et al. (2004) Blastomyces dermatitidis produces melanin in vitro and during infection. FEMS Microbiol Lett 239:187-93
Cheng, Yifan; Zak, Olga; Aisen, Philip et al. (2004) Structure of the human transferrin receptor-transferrin complex. Cell 116:565-76
Liu, Rutao; Guan, Jing-Qu; Zak, Olga et al. (2003) Structural reorganization of the transferrin C-lobe and transferrin receptor upon complex formation: the C-lobe binds to the receptor helical domain. Biochemistry 42:12447-54
Dhungana, Suraj; Taboy, Celine H; Anderson, Damon S et al. (2003) The influence of the synergistic anion on iron chelation by ferric binding protein, a bacterial transferrin. Proc Natl Acad Sci U S A 100:3659-64
Giannetti, Anthony M; Snow, Peter M; Zak, Olga et al. (2003) Mechanism for multiple ligand recognition by the human transferrin receptor. PLoS Biol 1:E51
Navati, Mahantesh S; Samuni, Uri; Aisen, Philip et al. (2003) Binding and release of iron by gel-encapsulated human transferrin: evidence for a conformational search. Proc Natl Acad Sci U S A 100:3832-7
Zak, Olga; Aisen, Philip (2003) Iron release from transferrin, its C-lobe, and their complexes with transferrin receptor: presence of N-lobe accelerates release from C-lobe at endosomal pH. Biochemistry 42:12330-4

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