Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK016073-21
Application #
2136976
Study Section
Biochemistry Study Section (BIO)
Project Start
1978-04-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
21
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Children's Hospital & Res Ctr at Oakland
Department
Type
DUNS #
City
Oakland
State
CA
Country
United States
Zip Code
94609
Brignole, Edward J; Asturias, Francisco (2010) Single-particle electron microscopy of animal fatty acid synthase describing macromolecular rearrangements that enable catalysis. Methods Enzymol 483:179-202
Brignole, Edward J; Smith, Stuart; Asturias, Francisco J (2009) Conformational flexibility of metazoan fatty acid synthase enables catalysis. Nat Struct Mol Biol 16:190-7
Bunkoczi, Gabor; Misquitta, Stephanie; Wu, Xiaoqiu et al. (2009) Structural basis for different specificities of acyltransferases associated with the human cytosolic and mitochondrial fatty acid synthases. Chem Biol 16:667-75
Smith, Stuart; Tsai, Shiou-Chuan (2007) The type I fatty acid and polyketide synthases: a tale of two megasynthases. Nat Prod Rep 24:1041-72
Pasta, Saloni; Witkowski, Andrzej; Joshi, Anil K et al. (2007) Catalytic residues are shared between two pseudosubunits of the dehydratase domain of the animal fatty acid synthase. Chem Biol 14:1377-85
Bunkoczi, Gabor; Pasta, Saloni; Joshi, Anil et al. (2007) Mechanism and substrate recognition of human holo ACP synthase. Chem Biol 14:1243-53
Joshi, Anil K; Witkowski, Andrzej; Berman, Harvey A et al. (2005) Effect of modification of the length and flexibility of the acyl carrier protein-thioesterase interdomain linker on functionality of the animal fatty acid synthase. Biochemistry 44:4100-7
Zhang, Lei; Joshi, Anil K; Hofmann, Jorg et al. (2005) Cloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strain. J Biol Chem 280:12422-9
Asturias, Francisco J; Chadick, James Z; Cheung, Iris K et al. (2005) Structure and molecular organization of mammalian fatty acid synthase. Nat Struct Mol Biol 12:225-32
Najjar, Sonia M; Yang, Yan; Fernstrom, Mats A et al. (2005) Insulin acutely decreases hepatic fatty acid synthase activity. Cell Metab 2:43-53

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