Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK016595-15S1
Application #
3225601
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1977-04-01
Project End
1991-03-31
Budget Start
1988-12-01
Budget End
1989-03-31
Support Year
15
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of California Riverside
Department
Type
Earth Sciences/Resources
DUNS #
City
Riverside
State
CA
Country
United States
Zip Code
92521
Okamura, William H; Zhu, Gui-Dong; Hill, David K et al. (2002) Synthesis and NMR studies of (13)C-labeled vitamin D metabolites. J Org Chem 67:1637-50
Hayashi, Rena; Fernandez, Susana; Okamura, William H (2002) An 8pi electron electrocyclization leading to a 9,19-methano-bridged analogue of 1 alpha,25-dihydroxyvitamin D3. Org Lett 4:851-4
Norman, Anthony W; Okamura, William H; Bishop, June E et al. (2002) Update on biological actions of 1alpha,25(OH)2-vitamin D3 (rapid effects) and 24R,25(OH)2-vitamin D3. Mol Cell Endocrinol 197:1-13
Okamura, W H; Do, S; Kim, H et al. (2001) Conformationally restricted mimics of vitamin D rotamers. Steroids 66:239-47
Norman, A W; Manchand, P S; Uskokovic, M R et al. (2000) Characterization of a novel analogue of 1alpha,25(OH)(2)-vitamin D(3) with two side chains: interaction with its nuclear receptor and cellular actions. J Med Chem 43:2719-30
Norman, A W; Song, X; Zanello, L et al. (1999) Rapid and genomic biological responses are mediated by different shapes of the agonist steroid hormone, 1alpha,25(OH)2vitamin D3. Steroids 64:120-8
Song, X; Bishop, J E; Okamura, W H et al. (1998) Stimulation of phosphorylation of mitogen-activated protein kinase by 1alpha,25-dihydroxyvitamin D3 in promyelocytic NB4 leukemia cells: a structure-function study. Endocrinology 139:457-65
Norman, A W; Okamura, W H; Hammond, M W et al. (1997) Comparison of 6-s-cis- and 6-s-trans-locked analogs of 1alpha,25-dihydroxyvitamin D3 indicates that the 6-s-cis conformation is preferred for rapid nongenomic biological responses and that neither 6-s-cis- nor 6-s-trans-locked analogs are preferred for ge Mol Endocrinol 11:1518-31
Muralidharan, K R; Rowland-Goldsmith, M; Lee, A S et al. (1997) Inhibitors of 25-hydroxyvitamin D3-1alpha-hydroxylase: thiavitamin D analogs and biological evaluation. J Steroid Biochem Mol Biol 62:73-8
Norman, A W; Bishop, J E; Collins, E D et al. (1996) Differing shapes of 1 alpha,25-dihydroxyvitamin D3 function as ligands for the D-binding protein, nuclear receptor and membrane receptor: a status report. J Steroid Biochem Mol Biol 56:13-22

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