Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK019974-19A1
Application #
2137423
Study Section
Endocrinology Study Section (END)
Project Start
1977-04-01
Project End
2001-01-30
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
19
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Rochester
Department
Pharmacology
Type
Schools of Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
Khan, Uniza Wahid; Øverli, Øyvind; Hinkle, Patricia M et al. (2016) A novel role for pigment genes in the stress response in rainbow trout (Oncorhynchus mykiss). Sci Rep 6:28969
Malik, Sundeep; Dolan, Terrance M; Maben, Zachary J et al. (2015) Adrenocorticotropic Hormone (ACTH) Responses Require Actions of the Melanocortin-2 Receptor Accessory Protein on the Extracellular Surface of the Plasma Membrane. J Biol Chem 290:27972-85
Wheeler, Sadie G; Hammond, Christine L; Jornayvaz, François R et al. (2014) Ost?-/- mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain, and modestly improved insulin sensitivity. Am J Physiol Gastrointest Liver Physiol 306:G425-38
Sebag, Julien A; Zhang, Chao; Hinkle, Patricia M et al. (2013) Developmental control of the melanocortin-4 receptor by MRAP2 proteins in zebrafish. Science 341:278-81
Gehret, Austin U; Hinkle, Patricia M (2013) siRNA screen identifies the phosphatase acting on the G protein-coupled thyrotropin-releasing hormone receptor. ACS Chem Biol 8:588-98
Christian, Whitney V; Li, Na; Hinkle, Patricia M et al. (2012) ?-Subunit of the Ost?-Ost? organic solute transporter is required not only for heterodimerization and trafficking but also for function. J Biol Chem 287:21233-43
Thal, David M; Homan, Kristoff T; Chen, Jun et al. (2012) Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. ACS Chem Biol 7:1830-9
Hinkle, Patricia M; Serasinghe, Madhavika N; Jakabowski, Andrea et al. (2011) Use of chimeric melanocortin-2 and -4 receptors to identify regions responsible for ligand specificity and dependence on melanocortin 2 receptor accessory protein. Eur J Pharmacol 660:94-102
Liang, Liang; Sebag, Julien A; Eagelston, Lauren et al. (2011) Functional expression of frog and rainbow trout melanocortin 2 receptors using heterologous MRAP1s. Gen Comp Endocrinol 174:5-14
Gehret, Austin U; Jones, Brian W; Tran, Phuong N et al. (2010) Role of helix 8 of the thyrotropin-releasing hormone receptor in phosphorylation by G protein-coupled receptor kinase. Mol Pharmacol 77:288-97

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