Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK020902-19
Application #
2137537
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1978-01-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
19
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
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Alangari, Abdullah; Al-Harbi, Abdullah; Al-Ghonaium, Abdulaziz et al. (2009) Purine nucleoside phosphorylase deficiency in two unrelated Saudi patients. Ann Saudi Med 29:309-12
Gracia, Eduard; Cortes, Antoni; Meana, J Javier et al. (2008) Human adenosine deaminase as an allosteric modulator of human A(1) adenosine receptor: abolishment of negative cooperativity for [H](R)-pia binding to the caudate nucleus. J Neurochem 107:161-70
Engel, Barbara C; Podsakoff, Greg M; Ireland, Joanna L et al. (2007) Prolonged pancytopenia in a gene therapy patient with ADA-deficient SCID and trisomy 8 mosaicism: a case report. Blood 109:503-6
Malacarne, Fabio; Benicchi, Tiziana; Notarangelo, Lucia Dora et al. (2005) Reduced thymic output, increased spontaneous apoptosis and oligoclonal B cells in polyethylene glycol-adenosine deaminase-treated patients. Eur J Immunol 35:3376-86
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Chan, Belinda; Wara, Diane; Bastian, John et al. (2005) Long-term efficacy of enzyme replacement therapy for adenosine deaminase (ADA)-deficient severe combined immunodeficiency (SCID). Clin Immunol 117:133-43
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Gonzalez-Gronow, Mario; Hershfield, Michael S; Arredondo-Vega, Francisco X et al. (2004) Cell surface adenosine deaminase binds and stimulates plasminogen activation on 1-LN human prostate cancer cells. J Biol Chem 279:20993-8
Myers, Laurie A; Hershfield, Michael S; Neale, Wirt T et al. (2004) Purine nucleoside phosphorylase deficiency (PNP-def) presenting with lymphopenia and developmental delay: successful correction with umbilical cord blood transplantation. J Pediatr 145:710-2

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