Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK021723-19
Application #
2137608
Study Section
Biochemistry Study Section (BIO)
Project Start
1978-09-15
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
19
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Washington
Department
Pharmacology
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Temkitthawon, Prapapan; Hinds, Thomas R; Beavo, Joseph A et al. (2011) Kaempferia parviflora, a plant used in traditional medicine to enhance sexual performance contains large amounts of low affinity PDE5 inhibitors. J Ethnopharmacol 137:1437-41
Percival, Justin M; Adamo, Candace M; Beavo, Joseph A et al. (2011) Evaluation of the therapeutic utility of phosphodiesterase 5A inhibition in the mdx mouse model of duchenne muscular dystrophy. Handb Exp Pharmacol :323-44
Surapisitchat, James; Beavo, Joseph A (2011) Regulation of endothelial barrier function by cyclic nucleotides: the role of phosphodiesterases. Handb Exp Pharmacol :193-210
Hertz, Angie L; Bender, Andrew T; Smith, Kimberly C et al. (2009) Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages. Proc Natl Acad Sci U S A 106:21978-83
Martinez, Sergio E; Heikaus, Clemens C; Klevit, Rachel E et al. (2008) The structure of the GAF A domain from phosphodiesterase 6C reveals determinants of cGMP binding, a conserved binding surface, and a large cGMP-dependent conformational change. J Biol Chem 283:25913-9
Poppe, Heiko; Rybalkin, Sergei D; Rehmann, Holger et al. (2008) Cyclic nucleotide analogs as probes of signaling pathways. Nat Methods 5:277-8
Surapisitchat, James; Jeon, Kye-Im; Yan, Chen et al. (2007) Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3. Circ Res 101:811-8
Conti, Marco; Beavo, Joseph (2007) Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Annu Rev Biochem 76:481-511
Askari, Bardia; Kanter, Jenny E; Sherrid, Ashley M et al. (2007) Rosiglitazone inhibits acyl-CoA synthetase activity and fatty acid partitioning to diacylglycerol and triacylglycerol via a peroxisome proliferator-activated receptor-gamma-independent mechanism in human arterial smooth muscle cells and macrophages. Diabetes 56:1143-52
Laxman, Sunil; Riechers, Aaron; Sadilek, Martin et al. (2006) Hydrolysis products of cAMP analogs cause transformation of Trypanosoma brucei from slender to stumpy-like forms. Proc Natl Acad Sci U S A 103:19194-9

Showing the most recent 10 out of 76 publications