Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK022122-19
Application #
2137649
Study Section
Metabolism Study Section (MET)
Project Start
1978-05-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
19
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Biochemistry
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Zelent, Bogumil; Raimondo, Anne; Barrett, Amy et al. (2014) Analysis of the co-operative interaction between the allosterically regulated proteins GK and GKRP using tryptophan fluorescence. Biochem J 459:551-64
Li, Changhong; Liu, Chengyang; Nissim, Itzhak et al. (2013) Regulation of glucagon secretion in normal and diabetic human islets by ?-hydroxybutyrate and glycine. J Biol Chem 288:3938-51
Zhang, Tingting; Li, Changhong (2013) Mechanisms of amino acid-stimulated insulin secretion in congenital hyperinsulinism. Acta Biochim Biophys Sin (Shanghai) 45:36-43
Prentki, Marc; Matschinsky, Franz M; Madiraju, S R Murthy (2013) Metabolic signaling in fuel-induced insulin secretion. Cell Metab 18:162-85
Doliba, Nicolai M; Qin, Wei; Najafi, Habiba et al. (2012) Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics. Am J Physiol Endocrinol Metab 302:E87-E102
Zelent, B; Buettger, C; Grimsby, J et al. (2012) Thermal stability of glucokinase (GK) as influenced by the substrate glucose, an allosteric glucokinase activator drug (GKA) and the osmolytes glycerol and urea. Biochim Biophys Acta 1824:769-84
Nissim, Itzhak; Horyn, Oksana; Nissim, Ilana et al. (2012) Effects of a glucokinase activator on hepatic intermediary metabolism: study with 13C-isotopomer-based metabolomics. Biochem J 444:537-51
Doliba, Nicolai M; Fenner, Deborah; Zelent, Bogumil et al. (2012) Repair of diverse diabetic defects of ?-cells in man and mouse by pharmacological glucokinase activation. Diabetes Obes Metab 14 Suppl 3:109-19
Fenner, Deborah; Odili, Stella; Hong, Hee-Kyung et al. (2011) Generation of N-ethyl-N-nitrosourea (ENU) diabetes models in mice demonstrates genotype-specific action of glucokinase activators. J Biol Chem 286:39560-72
Matschinsky, Franz M; Zelent, Bogumil; Doliba, Nicolai et al. (2011) Glucokinase activators for diabetes therapy: May 2010 status report. Diabetes Care 34 Suppl 2:S236-43

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