Abstract

The proposed research will evaluate the immunologic and environmental determinants of the risk of insulin dependent diabetes mellitus (IDDM). Specifically, we will: 1. Monitor the incidence of IDDM in Allegheny County, PA, over 25 years (1965-1990) as well as the world. 2. Assess the associations between specific serologic and molecular markers to the risk of IDDM in 90 multiple sibling families, 58 affected parent offspring families, and 60 single case families. 3. Evaluate the association between viral DNA insertion into the human genome and IDDM. 4. Continue to collect samples on first degree relatives of cases prior to conversion to IDDM.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK024021-12
Application #
3227251
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1978-09-15
Project End
1993-11-30
Budget Start
1989-12-01
Budget End
1990-11-30
Support Year
12
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Children's Hosp Pittsburgh/Upmc Health Sys
Department
Type
DUNS #
044304145
City
Pittsburgh
State
PA
Country
United States
Zip Code
15224

  Publications

Long, Anna E; Wilson, Isabel V; Becker, Dorothy J et al. (2018) Characteristics of slow progression to diabetes in multiple islet autoantibody-positive individuals from five longitudinal cohorts: the SNAIL study. Diabetologia 61:1484-1490
Hecht Baldauff, Natalie; Tfayli, Hala; Dong, Wenxiu et al. (2016) Relationship of adiponectin and leptin with autoimmunity in children with new-onset type 1 diabetes: a pilot study. Pediatr Diabetes 17:249-56
Buryk, Melissa A; Dosch, H-Michael; Libman, Ingrid et al. (2015) Neuronal T-cell autoreactivity is amplified in overweight children with new-onset insulin-requiring diabetes. Diabetes Care 38:43-50
Haidet, Jaime; Cifarelli, Vincenza; Trucco, Massimo et al. (2012) C-peptide reduces pro-inflammatory cytokine secretion in LPS-stimulated U937 monocytes in condition of hyperglycemia. Inflamm Res 61:27-35
Bonner, Samantha M; Pietropaolo, Susan L; Fan, Yong et al. (2012) Sequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-regulate expression. J Biol Chem 287:17882-93
Cifarelli, V; Geng, X; Styche, A et al. (2011) C-peptide reduces high-glucose-induced apoptosis of endothelial cells and decreases NAD(P)H-oxidase reactive oxygen species generation in human aortic endothelial cells. Diabetologia 54:2702-12
Morran, Michael P; Casu, Anna; Arena, Vincent C et al. (2010) Humoral autoimmunity against the extracellular domain of the neuroendocrine autoantigen IA-2 heightens the risk of type 1 diabetes. Endocrinology 151:2528-37
Luppi, P; Geng, X; Cifarelli, V et al. (2009) C-peptide is internalised in human endothelial and vascular smooth muscle cells via early endosomes. Diabetologia 52:2218-28
Ma, Xiaosu; Becker, Dorothy; Arena, Vincent C et al. (2009) The effect of age on insulin sensitivity and insulin secretion in first-degree relatives of type 1 diabetic patients: a population analysis. J Clin Endocrinol Metab 94:2446-51
Artz, Evelyn; Warren-Ulanch, Julia; Becker, Dorothy et al. (2008) Seropositivity to celiac antigens in asymptomatic children with type 1 diabetes mellitus: association with weight, height, and bone mineralization. Pediatr Diabetes 9:277-84

Showing the most recent 10 out of 81 publications