Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK024021-15S1
Application #
3227248
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1978-09-15
Project End
1994-03-31
Budget Start
1992-12-01
Budget End
1994-03-31
Support Year
15
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Children's Hosp Pittsburgh/Upmc Health Sys
Department
Type
DUNS #
044304145
City
Pittsburgh
State
PA
Country
United States
Zip Code
15224
Long, Anna E; Wilson, Isabel V; Becker, Dorothy J et al. (2018) Characteristics of slow progression to diabetes in multiple islet autoantibody-positive individuals from five longitudinal cohorts: the SNAIL study. Diabetologia 61:1484-1490
Hecht Baldauff, Natalie; Tfayli, Hala; Dong, Wenxiu et al. (2016) Relationship of adiponectin and leptin with autoimmunity in children with new-onset type 1 diabetes: a pilot study. Pediatr Diabetes 17:249-56
Buryk, Melissa A; Dosch, H-Michael; Libman, Ingrid et al. (2015) Neuronal T-cell autoreactivity is amplified in overweight children with new-onset insulin-requiring diabetes. Diabetes Care 38:43-50
Haidet, Jaime; Cifarelli, Vincenza; Trucco, Massimo et al. (2012) C-peptide reduces pro-inflammatory cytokine secretion in LPS-stimulated U937 monocytes in condition of hyperglycemia. Inflamm Res 61:27-35
Bonner, Samantha M; Pietropaolo, Susan L; Fan, Yong et al. (2012) Sequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-regulate expression. J Biol Chem 287:17882-93
Cifarelli, V; Geng, X; Styche, A et al. (2011) C-peptide reduces high-glucose-induced apoptosis of endothelial cells and decreases NAD(P)H-oxidase reactive oxygen species generation in human aortic endothelial cells. Diabetologia 54:2702-12
Morran, Michael P; Casu, Anna; Arena, Vincent C et al. (2010) Humoral autoimmunity against the extracellular domain of the neuroendocrine autoantigen IA-2 heightens the risk of type 1 diabetes. Endocrinology 151:2528-37
Luppi, P; Geng, X; Cifarelli, V et al. (2009) C-peptide is internalised in human endothelial and vascular smooth muscle cells via early endosomes. Diabetologia 52:2218-28
Ma, Xiaosu; Becker, Dorothy; Arena, Vincent C et al. (2009) The effect of age on insulin sensitivity and insulin secretion in first-degree relatives of type 1 diabetic patients: a population analysis. J Clin Endocrinol Metab 94:2446-51
Artz, Evelyn; Warren-Ulanch, Julia; Becker, Dorothy et al. (2008) Seropositivity to celiac antigens in asymptomatic children with type 1 diabetes mellitus: association with weight, height, and bone mineralization. Pediatr Diabetes 9:277-84

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