Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK026438-15S1
Application #
2137861
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1979-12-01
Project End
1996-03-31
Budget Start
1995-09-30
Budget End
1996-03-31
Support Year
15
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10029
Bradbury, Michael W; Stump, Decherd; Guarnieri, Frank et al. (2011) Molecular modeling and functional confirmation of a predicted fatty acid binding site of mitochondrial aspartate aminotransferase. J Mol Biol 412:412-22
Berk, Paul D (2008) Regulatable fatty acid transport mechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome. Hepatology 48:1362-76
Petrescu, O; Fan, X; Gentileschi, P et al. (2005) Long-chain fatty acid uptake is upregulated in omental adipocytes from patients undergoing bariatric surgery for obesity. Int J Obes (Lond) 29:196-203
Berk, Paul D; Zhou, Shengli; Bradbury, Michael W (2005) Increased hepatocellular uptake of long chain fatty acids occurs by different mechanisms in fatty livers due to obesity or excess ethanol use, contributing to development of steatohepatitis in both settings. Trans Am Clin Climatol Assoc 116:335-44; discussion 345
Grodstein, Francine; Fretts, Ruth; Lifford, Karen et al. (2003) Association of age, race, and obstetric history with urinary symptoms among women in the Nurses' Health Study. Am J Obstet Gynecol 189:428-34
Fan, Xinqing; Bradbury, Michael W; Berk, Paul D (2003) Leptin and insulin modulate nutrient partitioning and weight loss in ob/ob mice through regulation of long-chain fatty acid uptake by adipocytes. J Nutr 133:2707-15
Cechetto, J D; Sadacharan, S K; Berk, P D et al. (2002) Immunogold localization of mitochondrial aspartate aminotransferase in mitochondria and on the cell surface in normal rat tissues. Histol Histopathol 17:353-64
Stump, D D; Fan, X; Berk, P D (2001) Oleic acid uptake and binding by rat adipocytes define dual pathways for cellular fatty acid uptake. J Lipid Res 42:509-20
Bradbury, M W; Berk, P D (2000) Mitochondrial aspartate aminotransferase: direction of a single protein with two distinct functions to two subcellular sites does not require alternative splicing of the mRNA. Biochem J 345 Pt 3:423-7
Berk, P D; Zhou, S; Kiang, C et al. (1999) Selective up-regulation of fatty acid uptake by adipocytes characterizes both genetic and diet-induced obesity in rodents. J Biol Chem 274:28626-31

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