Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK028554-16
Application #
2138185
Study Section
Biochemistry Study Section (BIO)
Project Start
1980-09-01
Project End
1997-11-30
Budget Start
1995-12-21
Budget End
1996-11-30
Support Year
16
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Garcia-Pavia, Pablo; Torres, Rosa J; Rivero, Manuel et al. (2003) Phosphoribosylpyrophosphate synthetase overactivity as a cause of uric acid overproduction in a young woman. Arthritis Rheum 48:2036-41
Becker, M A (2001) Phosphoribosylpyrophosphate synthetase and the regulation of phosphoribosylpyrophosphate production in human cells. Prog Nucleic Acid Res Mol Biol 69:115-48
Becker, M A; Ahmed, M (2000) Cell type-specific differential expression of human PRPP synthetase (PRPS) genes. Adv Exp Med Biol 486:10-May
Ahmed, M; Taylor, W; Smith, P R et al. (1999) Accelerated transcription of PRPS1 in X-linked overactivity of normal human phosphoribosylpyrophosphate synthetase. J Biol Chem 274:7482-8
Becker, M A; Taylor, W; Smith, P R et al. (1998) Regulation of human PRS isoform expression. Adv Exp Med Biol 431:215-20
Becker, M A; Taylor, W; Smith, P R et al. (1996) Overexpression of the normal phosphoribosylpyrophosphate synthetase 1 isoform underlies catalytic superactivity of human phosphoribosylpyrophosphate synthetase. J Biol Chem 271:19894-9
Becker, M A; Smith, P R; Taylor, W et al. (1995) The genetic and functional basis of purine nucleotide feedback-resistant phosphoribosylpyrophosphate synthetase superactivity. J Clin Invest 96:2133-41
Fry, D W; Becker, M A; Switzer, R L (1995) Inhibition of human 5-phosphoribosyl-1-pyrophosphate synthetase by 4-amino-8-(beta-D-ribofuranosylamino)-pyrimido[5,4-d]pyrimidine-5'- monophosphate: evidence for interaction at the ADP allosteric site. Mol Pharmacol 47:810-5
Becker, M A; Nosal, J M; Switzer, R L et al. (1994) Point mutations in PRPS1, the gene encoding the PRPP synthetase (PRS) 1 isoform, underlie X-linked PRS superactivity associated with purine nucleotide inhibitor-resistance. Adv Exp Med Biol 370:707-10
Roessler, B J; Nosal, J M; Smith, P R et al. (1993) Human X-linked phosphoribosylpyrophosphate synthetase superactivity is associated with distinct point mutations in the PRPS1 gene. J Biol Chem 268:26476-81

Showing the most recent 10 out of 20 publications