Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK029902-10
Application #
3229110
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1981-07-01
Project End
1990-08-31
Budget Start
1990-07-01
Budget End
1990-08-31
Support Year
10
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Iowa
Department
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Ginder, Gordon D; Williams Jr, David C (2018) Readers of DNA methylation, the MBD family as potential therapeutic targets. Pharmacol Ther 184:98-111
Desai, Megha A; Webb, Heather D; Sinanan, Leander M et al. (2015) An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex. Nucleic Acids Res 43:3100-13
Sperlazza, Justin; Rahmani, Mohamed; Beckta, Jason et al. (2015) Depletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formation. Blood 126:1462-72
Ginder, Gordon D (2015) Epigenetic regulation of fetal globin gene expression in adult erythroid cells. Transl Res 165:115-25
Cramer, Jason M; Scarsdale, J Neel; Walavalkar, Ninad M et al. (2014) Probing the dynamic distribution of bound states for methylcytosine-binding domains on DNA. J Biol Chem 289:1294-302
Amaya, Maria; Desai, Megha; Gnanapragasam, Merlin Nithya et al. (2013) Mi2?-mediated silencing of the fetal ?-globin gene in adult erythroid cells. Blood 121:3493-501
Rupon, Jeremy W; Wang, Shou Zhen; Gnanapragasam, Merlin et al. (2011) MBD2 contributes to developmental silencing of the human ?-globin gene. Blood Cells Mol Dis 46:212-9
Gnanapragasam, Merlin Nithya; Scarsdale, J Neel; Amaya, Maria L et al. (2011) p66Alpha-MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2-NuRD complex. Proc Natl Acad Sci U S A 108:7487-92
Ginder, Gordon D; Gnanapragasam, Merlin N; Mian, Omar Y (2008) The role of the epigenetic signal, DNA methylation, in gene regulation during erythroid development. Curr Top Dev Biol 82:85-116
Rupon, Jeremy W; Wang, Shou Zhen; Gaensler, Karin et al. (2006) Methyl binding domain protein 2 mediates gamma-globin gene silencing in adult human betaYAC transgenic mice. Proc Natl Acad Sci U S A 103:6617-22

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