Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK030312-19
Application #
6131691
Study Section
General Medicine A Subcommittee 2 (GMA)
Program Officer
Serrano, Jose
Project Start
1982-02-01
Project End
2005-05-31
Budget Start
2000-06-01
Budget End
2001-05-31
Support Year
19
Fiscal Year
2000
Total Cost
$408,750
Indirect Cost
Name
University of Southern California
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Han, Derick; Hanawa, Naoko; Saberi, Behnam et al. (2006) Hydrogen peroxide and redox modulation sensitize primary mouse hepatocytes to TNF-induced apoptosis. Free Radic Biol Med 41:627-39
Liu, Zhang-Xu; Han, Derick; Gunawan, Basuki et al. (2006) Neutrophil depletion protects against murine acetaminophen hepatotoxicity. Hepatology 43:1220-30
Gunawan, Basuki K; Liu, Zhang-Xu; Han, Derick et al. (2006) c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gastroenterology 131:165-78
Liu, Zhang-Xu; Govindarajan, Sugantha; Kaplowitz, Neil (2004) Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Gastroenterology 127:1760-74
Lou, Huan; Ookhtens, Murad; Stolz, Andrew et al. (2003) Chelerythrine stimulates GSH transport by rat Mrp2 (Abcc2) expressed in canine kidney cells. Am J Physiol Gastrointest Liver Physiol 285:G1335-44
Mittur, Aravind; Wolkoff, Allan W; Kaplowitz, Neil (2002) The thiol sensitivity of glutathione transport in sidedness-sorted basolateral liver plasma membrane and in Oatp1-expressing HeLa cell membrane. Mol Pharmacol 61:425-35
Lu, S C; Kuhlenkamp, J; Wu, H et al. (1997) Progressive defect in biliary GSH secretion in streptozotocin-induced diabetic rats. Am J Physiol 272:G374-82
Fernandez-Checa, J C; Yi, J R; Garcia Ruiz, C et al. (1996) Plasma membrane and mitochondrial transport of hepatic reduced glutathione. Semin Liver Dis 16:147-58
Kaplowitz, N; Tsukamoto, H (1996) Oxidative stress and liver disease. Prog Liver Dis 14:131-59
Kannan, R; Yi, J R; Tang, D et al. (1996) Evidence for the existence of a sodium-dependent glutathione (GSH) transporter. Expression of bovine brain capillary mRNA and size fractions in Xenopus laevis oocytes and dissociation from gamma-glutamyltranspeptidase and facilitative GSH transporters. J Biol Chem 271:9754-8

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