Physiology of Glutathione Efflux From the Liver

Kaplowitz, Neil

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 5R01DK030312-21
• Application #: 6517039
• Study Section: General Medicine A Subcommittee 2 (GMA)
• Program Officer: Serrano, Jose
• Project Start: 1982-02-01
• Project End: 2005-05-31
• Budget Start: 2002-06-01
• Budget End: 2003-05-31
• Support Year: 21
• Fiscal Year: 2002
• Total Cost: $406,250

Institution

• Name: University of Southern California
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 041544081
• City: Los Angeles
• State: CA
• Country: United States
• Zip Code: 90089

Publications

Han, Derick; Hanawa, Naoko; Saberi, Behnam et al. (2006) Hydrogen peroxide and redox modulation sensitize primary mouse hepatocytes to TNF-induced apoptosis. Free Radic Biol Med 41:627-39

Liu, Zhang-Xu; Han, Derick; Gunawan, Basuki et al. (2006) Neutrophil depletion protects against murine acetaminophen hepatotoxicity. Hepatology 43:1220-30

Gunawan, Basuki K; Liu, Zhang-Xu; Han, Derick et al. (2006) c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gastroenterology 131:165-78

Liu, Zhang-Xu; Govindarajan, Sugantha; Kaplowitz, Neil (2004) Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Gastroenterology 127:1760-74

Lou, Huan; Ookhtens, Murad; Stolz, Andrew et al. (2003) Chelerythrine stimulates GSH transport by rat Mrp2 (Abcc2) expressed in canine kidney cells. Am J Physiol Gastrointest Liver Physiol 285:G1335-44

Mittur, Aravind; Wolkoff, Allan W; Kaplowitz, Neil (2002) The thiol sensitivity of glutathione transport in sidedness-sorted basolateral liver plasma membrane and in Oatp1-expressing HeLa cell membrane. Mol Pharmacol 61:425-35

Lu, S C; Kuhlenkamp, J; Wu, H et al. (1997) Progressive defect in biliary GSH secretion in streptozotocin-induced diabetic rats. Am J Physiol 272:G374-82

Kannan, R; Yi, J R; Tang, D et al. (1996) Evidence for the existence of a sodium-dependent glutathione (GSH) transporter. Expression of bovine brain capillary mRNA and size fractions in Xenopus laevis oocytes and dissociation from gamma-glutamyltranspeptidase and facilitative GSH transporters. J Biol Chem 271:9754-8

Kaplowitz, N; Fernandez-Checa, J C; Kannan, R et al. (1996) GSH transporters: molecular characterization and role in GSH homeostasis. Biol Chem Hoppe Seyler 377:267-73

Lu, S C; Sun, W M; Yi, J et al. (1996) Role of two recently cloned rat liver GSH transporters in the ubiquitous transport of GSH in mammalian cells. J Clin Invest 97:1488-96