Abstract

Non-insulin-dependent diabetes mellitus (NIDDM) is more prevalent in Japanese Americans than in either native Japanese or the general U.S. White population. The goal is to study longitudinally the development of abnormal glucose tolerance in relation to risk factors already found to be associated with NIDDM in older (45-74 yr) Japanese Americans in the cross- sectional analyses of our previous studies. The following is our general hypothesis: The high prevalence of NIDDM in Japanese Americans results from the interaction of familial factors and environmental (behavioral) factors reflecting """"""""westernization"""""""", such as nutrition, physical activity, acculturation, and phychosocial stress, to increase the prevalence of insulin resistance, hyperinsulinemia, hyperglycemia, and weight gain with preferential truncal fat deposition, responses modified by gender and menopausal status of females.
Our specific aim i s: To continue longitudinal study of risk factors in the development of NIDDM in a cohort of older non-diabetic second-generation Japanese-American men and (post-menopausal) women in King County, Washington, and expand the third generation baseline sample and complete cross-sectional analyses in preparation for future longitudinal studies on the development of NIDDM in third-generation men and (currently premenopausal) women.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK031170-09A2
Application #
3229916
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1983-06-01
Project End
1996-07-31
Budget Start
1992-08-01
Budget End
1993-07-31
Support Year
9
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Han, Seung Jin; Boyko, Edward J; Kim, Soo Kyung et al. (2018) Association of Thigh Muscle Mass with Insulin Resistance and Incident Type 2 Diabetes Mellitus in Japanese Americans. Diabetes Metab J 42:488-495
Wander, Pandora L; Hayashi, Tomoshige; Sato, Kyoko Kogawa et al. (2018) Design and validation of a novel estimator of visceral adipose tissue area and comparison to existing adiposity surrogates. J Diabetes Complications 32:1062-1067
Han, Seung Jin; Fujimoto, Wilfred Y; Kahn, Steven E et al. (2018) Change in visceral adiposity is an independent predictor of future arterial pulse pressure. J Hypertens 36:299-305
Han, Seung Jin; Kim, Soo-Kyung; Fujimoto, Wilfred Y et al. (2017) Effects of combination of change in visceral fat and thigh muscle mass on the development of type 2 diabetes. Diabetes Res Clin Pract 134:131-138
Lee, Crystal Man Ying; Woodward, Mark; Pandeya, Nirmala et al. (2017) Comparison of relationships between four common anthropometric measures and incident diabetes. Diabetes Res Clin Pract 132:36-44
Han, Seung Jin; Boyko, Edward J; Fujimoto, Wilfred Y et al. (2017) Low Plasma Adiponectin Concentrations Predict Increases in Visceral Adiposity and Insulin Resistance. J Clin Endocrinol Metab 102:4626-4633
Kocarnik, Beverly M; Boyko, Edward J; Matsumoto, Alvin M et al. (2016) Baseline estradiol concentration in community-dwelling Japanese American men is not associated with intra-abdominal fat accumulation over 10 years. Obes Res Clin Pract 10:624-632
Sullivan, Catherine A; Kahn, Steven E; Fujimoto, Wilfred Y et al. (2015) Change in Intra-Abdominal Fat Predicts the Risk of Hypertension in Japanese Americans. Hypertension 66:134-40
Hwang, Y-C; Hayashi, T; Fujimoto, W Y et al. (2015) Visceral abdominal fat accumulation predicts the conversion of metabolically healthy obese subjects to an unhealthy phenotype. Int J Obes (Lond) 39:1365-70
Araneta, Maria Rosario G; Kanaya, Alka M; Hsu, William C et al. (2015) Optimum BMI cut points to screen asian americans for type 2 diabetes. Diabetes Care 38:814-20

Showing the most recent 10 out of 23 publications