This is a prospective study designed to further define the prevalence, incidence, morbidity and mortality of non-insulin dependent (Type II) diabetes mellitus and of fasting hyperglycemia in a previously characterized adult community. In 1972-74, 82 percent of a geographically defined population (n=4382) aged 40-79 participated in a heart disease risk factor survey that included a medical and cigarette smoking history and measurements of height, weight, blood pressure, cholesterol, triglyceride and fasting plasma glucose (FPG). In 1974-76, approximately one-third of this cohort (n=1403) was examined more extensively, including repeat mesurements of FPG, lipids and lipoproteins, medication, alcohol and cigarette use, resting and exercise ECG and 24-hour diet recall. Approximately half of this subset (n=624) had a third visit in 1978-79 which included all of the above biochemical and behavioral assessments, glycosylated hemoglobin, self-reported particulars related to the diagnosis, duration and severity of diabetes, and four non-invasive tests for peripheral arterial disease. The entire cohort has been followed for mortality to the present, with 99 percent ascertainment in this, the 8th followup year. We propose to a) validate and characterize the diagnosis of diabetes in all members of the original cohort who then or subsequently identified themselves as diabetic, b) reexamine 3000 surviving members of this cohort an average of 10 years after the first visit in order to obtain data on diabetes incidence and cardiovascular, retinal and renal morbidity, and c) extend the mortality followup an additional five years in order to examine 15-year all-cause and cardiovascular mortality as related to diabetes and to borderline fasting hyperglycemia after adjusting for the effect of previously measured covariates.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK031801-04
Application #
3230346
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1983-07-01
Project End
1988-06-30
Budget Start
1986-07-01
Budget End
1987-06-30
Support Year
4
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Inker, Lesley A; Grams, Morgan E; Levey, Andrew S et al. (2018) Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium. Am J Kidney Dis :
Wright, N C; Hooker, E R; Nielson, C M et al. (2018) The epidemiology of wrist fractures in older men: the Osteoporotic Fractures in Men (MrOS) study. Osteoporos Int 29:859-870
Mohler 3rd, Emile R; Ellenberg, Susan S; Lewis, Cora E et al. (2018) The Effect of Testosterone on Cardiovascular Biomarkers in the Testosterone Trials. J Clin Endocrinol Metab 103:681-688
Thomas, Bernadette; Matsushita, Kunihiro; Abate, Kalkidan Hassen et al. (2017) Global Cardiovascular and Renal Outcomes of Reduced GFR. J Am Soc Nephrol 28:2167-2179
Richard, Erin L; Kritz-Silverstein, Donna; Laughlin, Gail A et al. (2017) Alcohol Intake and Cognitively Healthy Longevity in Community-Dwelling Adults: The Rancho Bernardo Study. J Alzheimers Dis 59:803-814
Mills, Paul J; Kania-Korwel, Izabela; Fagan, John et al. (2017) Excretion of the Herbicide Glyphosate in Older Adults Between 1993 and 2016. JAMA 318:1610-1611
Katzman, Wendy B; Huang, Mei-Hua; Kritz-Silverstein, Donna et al. (2017) Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Impaired Physical Function: The Rancho Bernardo Study. J Am Geriatr Soc 65:1476-1481
Kritz-Silverstein, D; Laughlin, G A; McEvoy, L K et al. (2017) Sex and Age Differences in the Association of Blood Pressure and Hypertension with Cognitive Function in the Elderly: The Rancho Bernardo Study. J Prev Alzheimers Dis 4:165-173
Reas, Emilie T; Laughlin, Gail A; Bergstrom, Jaclyn et al. (2017) Effects of Sex and Education on Cognitive Change Over a 27-Year Period in Older Adults: The Rancho Bernardo Study. Am J Geriatr Psychiatry 25:889-899
Lee, Crystal Man Ying; Woodward, Mark; Pandeya, Nirmala et al. (2017) Comparison of relationships between four common anthropometric measures and incident diabetes. Diabetes Res Clin Pract 132:36-44

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