The overall goal of this proposal is to continue the population- based Registry of incident insulin-dependent diabetes mellitus (IDDM) that was started with NIH funding in 1983 in the State of Colorado. Two new protocols are also proposed as natural extensions of the core Registry. One will describe the level of glucose control in persons with IDDM, statewide; and the second will characterize Hispanics with IDDM, who were found during the first grant period to have only one-half the risk of Anglo persons with IDDM.
The specific aims are: 1) To determine the incidence of IDDM under the age of 18 years by sociodemographic, temporal, and ethnic variables for persons in the state of Colorado 2) To prospectively estimate the level of blood glucose control using a mailed filter paper method for glycosylated hemoglobin 3) To characterize Hispanic persons with IDDM on an epidemiologic, clinical, racial, and immunological basis compared to Anglos.
These specific aims will be achieved through 4 principal activities. First, physician-based case-ascertainment will be maintained and validated. Second, follow-up will be continued for acute and chronic complications as determined by questionnaire to assess the natural histroy of IDDM. Third, glycosylated hemoglobins will be obtained to characterize glucose control and prepare for a detailed complications review. Fourth, Hispanics and appropriate Anglos will be studied to determine if clinical, biochemical, immunologic, and genetic characteristics differ for Hispanics with IDDM
| Steck, Andrea K; Dong, Fran; Frohnert, Brigitte I et al. (2018) Predicting progression to diabetes in islet autoantibody positive children. J Autoimmun 90:59-63 |
| Liu, Chih-Wei; Bramer, Lisa; Webb-Robertson, Bobbie-Jo et al. (2018) Temporal expression profiling of plasma proteins reveals oxidative stress in early stages of Type 1 Diabetes progression. J Proteomics 172:100-110 |
| Frohnert, Brigitte I; Laimighofer, Michael; Krumsiek, Jan et al. (2018) Prediction of type 1 diabetes using a genetic risk model in the Diabetes Autoimmunity Study in the Young. Pediatr Diabetes 19:277-283 |
| Liu, Chih-Wei; Bramer, Lisa; Webb-Robertson, Bobbie-Jo et al. (2017) Temporal profiles of plasma proteome during childhood development. J Proteomics 152:321-328 |
| Waugh, Kathleen; Snell-Bergeon, Janet; Michels, Aaron et al. (2017) Increased inflammation is associated with islet autoimmunity and type 1 diabetes in the Diabetes Autoimmunity Study in the Young (DAISY). PLoS One 12:e0174840 |
| Gu, Yong; Zhao, Zhiyuan; High, Hilary et al. (2017) Islet Autoantibody Detection by Electrochemiluminescence (ECL) Assay. J Clin Cell Immunol 8: |
| Liu, Edwin; Dong, Fran; Barón, Anna E et al. (2017) High Incidence of Celiac Disease in a Long-term Study of Adolescents With Susceptibility Genotypes. Gastroenterology 152:1329-1336.e1 |
| Frohnert, Brigitte I; Ide, Lisa; Dong, Fran et al. (2017) Late-onset islet autoimmunity in childhood: the Diabetes Autoimmunity Study in the Young (DAISY). Diabetologia 60:998-1006 |
| Yu, Liping; Zhao, Zhiyuan; Steck, Andrea K (2017) T1D Autoantibodies: room for improvement? Curr Opin Endocrinol Diabetes Obes 24:285-291 |
| Gesualdo, Patricia D; Bautista, Kimberly A; Waugh, Kathleen C et al. (2016) Feasibility of screening for T1D and celiac disease in a pediatric clinic setting. Pediatr Diabetes 17:441-8 |
Showing the most recent 10 out of 194 publications
