Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK032852-11
Application #
2138894
Study Section
Metabolism Study Section (MET)
Project Start
1983-08-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1998-04-30
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
San Diego State University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
073371346
City
San Diego
State
CA
Country
United States
Zip Code
92182

  Publications

Aboushadi, N; Shackelford, J E; Jessani, N et al. (2000) Characterization of peroxisomal 3-hydroxy-3-methylglutaryl coenzyme A reductase in UT2 cells: sterol biosynthesis, phosphorylation, degradation, and statin inhibition. Biochemistry 39:237-47
Olivier, L M; Chambliss, K L; Gibson, K M et al. (1999) Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting. J Lipid Res 40:672-9
Aboushadi, N; Krisans, S K (1998) Analysis of isoprenoid biosynthesis in peroxisomal-deficient Pex2 CHO cell lines. J Lipid Res 39:1781-91
Engfelt, W H; Masuda, K R; Paton, V G et al. (1998) Splice donor site mutations in the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene cause a deficiency of the endoplasmic reticulum 3-hydroxy-3-methylglutaryl coenzyme A reductase protein in UT2 cells. J Lipid Res 39:2182-91
Engfelt, W H; Shackelford, J E; Aboushadi, N et al. (1997) Characterization of UT2 cells. The induction of peroxisomal 3-hydroxy-3-methylglutaryl-coenzyme a reductase. J Biol Chem 272:24579-87
Paton, V G; Shackelford, J E; Krisans, S K (1997) Cloning and subcellular localization of hamster and rat isopentenyl diphosphate dimethylallyl diphosphate isomerase. A PTS1 motif targets the enzyme to peroxisomes. J Biol Chem 272:18945-50
Westfall, D; Aboushadi, N; Shackelford, J E et al. (1997) Metabolism of farnesol: phosphorylation of farnesol by rat liver microsomal and peroxisomal fractions. Biochem Biophys Res Commun 230:562-8
Krisans, S K (1996) Cell compartmentalization of cholesterol biosynthesis. Ann N Y Acad Sci 804:142-64
Biardi, L; Krisans, S K (1996) Compartmentalization of cholesterol biosynthesis. Conversion of mevalonate to farnesyl diphosphate occurs in the peroxisomes. J Biol Chem 271:1784-8
Biardi, L; Sreedhar, A; Zokaei, A et al. (1994) Mevalonate kinase is predominantly localized in peroxisomes and is defective in patients with peroxisome deficiency disorders. J Biol Chem 269:1197-205

Showing the most recent 10 out of 19 publications