Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK032999-15
Application #
2138949
Study Section
Metallobiochemistry Study Section (BMT)
Project Start
1983-11-30
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Berkeley
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
094878337
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Jurchen, Kristy M Clarke; Raymond, Kenneth N (2006) Terephthalamide-containing analogues of TREN-Me-3,2-HOPO. Inorg Chem 45:1078-90
Barnes, Carmen M; Petoud, Stephane; Cohen, Seth M et al. (2003) Competition studies in horse spleen ferritin probed by a kinetically inert inhibitor, [Cr(TREN)(H(2)O)(OH)](2+), and a highly luminescent Tb(III) reagent. J Biol Inorg Chem 8:195-205
Barnes, Carmen M; Theil, Elizabeth C; Raymond, Kenneth N (2002) Iron uptake in ferritin is blocked by binding of [Cr(TREN)(H(2)O)(OH)](2+), a slow dissociating model for [Fe(H(2)O)(6)](2+). Proc Natl Acad Sci U S A 99:5195-200
Xu, Jide; O'Sullivan, Brendon; Raymond, Kenneth N (2002) Hexadentate hydroxypyridonate iron chelators based on TREN-Me-3,2-HOPO: variation of cap size. Inorg Chem 41:6731-42
Sunderland, C J; Botta, M; Aime, S et al. (2001) 6-carboxamido-5,4-hydroxypyrimidinones: a new class of heterocyclic ligands and their evaluation as gadolinium chelating agents. Inorg Chem 40:6746-56
Johnson, A R; O'Sullivan, B; Raymond, K N (2000) Synthesis of a ligand based upon a new entry into the 3-hydroxy-N-alkyl-2(1H)-pyridinone ring system and thermodynamic evaluation of its gadolinium complex. Inorg Chem 39:2652-60
Cohen, S M; O'Sullivan, B; Raymond, K N (2000) Mixed hydroxypyridinonate ligands as iron chelators. Inorg Chem 39:4339-46
Turcot, I; Stintzi, A; Xu, J et al. (2000) Fast biological iron chelators: kinetics of iron removal from human diferric transferrin by multidentate hydroxypyridonates. J Biol Inorg Chem 5:634-41
Yokel, R A; Fredenburg, A M; Durbin, P W et al. (2000) The hexadentate hydroxypyridinonate TREN-(Me-3,2-HOPO) is a more orally active iron chelator than its bidentate analogue. J Pharm Sci 89:545-55