Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK033501-12A1
Application #
6370811
Study Section
Special Emphasis Panel (ZRG1-UROL (01))
Program Officer
Chang, Debuene
Project Start
1983-08-01
Project End
2005-06-30
Budget Start
2001-09-01
Budget End
2002-06-30
Support Year
12
Fiscal Year
2001
Total Cost
$308,421
Indirect Cost
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Weaver, Matthew L; Qiu, S Roger; Hoyer, John R et al. (2009) Surface aggregation of urinary proteins and aspartic Acid-rich peptides on the faces of calcium oxalate monohydrate investigated by in situ force microscopy. Calcif Tissue Int 84:462-73
Wang, Lijun; Qiu, S Roger; Zachowicz, William et al. (2006) Modulation of calcium oxalate crystallization by linear aspartic acid-rich peptides. Langmuir 22:7279-85
Tang, R; Nancollas, G H; Giocondi, J L et al. (2006) Dual roles of brushite crystals in calcium oxalate crystallization provide physicochemical mechanisms underlying renal stone formation. Kidney Int 70:71-8
De Yoreo, James J; Qiu, S Roger; Hoyer, John R (2006) Molecular modulation of calcium oxalate crystallization. Am J Physiol Renal Physiol 291:F1123-31
Weaver, Matthew L; Qiu, S Roger; Hoyer, John R et al. (2006) Improved model for inhibition of pathological mineralization based on citrate-calcium oxalate monohydrate interaction. Chemphyschem 7:2081-4
Elhadj, S; De Yoreo, J J; Hoyer, J R et al. (2006) Role of molecular charge and hydrophilicity in regulating the kinetics of crystal growth. Proc Natl Acad Sci U S A 103:19237-42
Qiu, S Roger; Wierzbicki, Andrzej; Salter, E Alan et al. (2005) Modulation of calcium oxalate monohydrate crystallization by citrate through selective binding to atomic steps. J Am Chem Soc 127:9036-44
Bleyer, Anthony J; Hart, Thomas C; Shihabi, Zak et al. (2004) Mutations in the uromodulin gene decrease urinary excretion of Tamm-Horsfall protein. Kidney Int 66:974-7
Qiu, S R; Wierzbicki, A; Orme, C A et al. (2004) Molecular modulation of calcium oxalate crystallization by osteopontin and citrate. Proc Natl Acad Sci U S A 101:1811-5
Hoyer, J R; Asplin, J R; Otvos, L (2001) Phosphorylated osteopontin peptides suppress crystallization by inhibiting the growth of calcium oxalate crystals. Kidney Int 60:77-82

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