Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK034151-11S1
Application #
2139242
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1984-08-01
Project End
1995-08-31
Budget Start
1994-09-01
Budget End
1995-08-31
Support Year
11
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Virginia Commonwealth University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
Alzoghaibi, Mohammad A; Walsh, Scott W; Willey, Amy et al. (2004) Linoleic acid induces interleukin-8 production by Crohn's human intestinal smooth muscle cells via arachidonic acid metabolites. Am J Physiol Gastrointest Liver Physiol 286:G528-37
Alzoghaibi, M A; Walsh, S W; Willey, A et al. (2003) Linoleic acid, but not oleic acid, upregulates the production of interleukin-8 by human intestinal smooth muscle cells isolated from patients with Crohn's disease. Clin Nutr 22:529-35
Graham, Martin; Willey, Amy (2003) Isolation, culture, and characterization of human intestinal smooth muscle cells. Methods Mol Med 78:417-23
Redman, Tamara K; Britt, William J; Wilcox, C Mel et al. (2002) Human cytomegalovirus enhances chemokine production by lipopolysaccharide-stimulated lamina propria macrophages. J Infect Dis 185:584-90
Smith, P D; Smythies, L E; Mosteller-Barnum, M et al. (2001) Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS- and IgA-mediated activities. J Immunol 167:2651-6
Natarajan, R; Ghosh, S; Fisher, B J et al. (2001) Redox imbalance in Crohn's disease intestinal smooth muscle cells causes NF-kappaB-mediated spontaneous interleukin-8 secretion. J Interferon Cytokine Res 21:349-59
Ehrlich, H P; Allison, G M; Page, M J et al. (2000) Increased gelsolin expression and retarded collagen lattice contraction with smooth muscle cells from Crohn's diseased intestine. J Cell Physiol 182:303-9
Li, L; Meng, G; Graham, M F et al. (1999) Intestinal macrophages display reduced permissiveness to human immunodeficiency virus 1 and decreased surface CCR5. Gastroenterology 116:1043-53
Rosenblat, G; Willey, A; Zhu, Y N et al. (1999) Palmitoyl ascorbate: selective augmentation of procollagen mRNA expression compared with L-ascorbate in human intestinal smooth muscle cells. J Cell Biochem 73:312-20
Harris, P R; Ernst, P B; Kawabata, S et al. (1998) Recombinant Helicobacter pylori urease activates primary mucosal macrophages. J Infect Dis 178:1516-20

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