Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK034804-10
Application #
2139375
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1995-09-30
Project End
2000-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Pathology
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Bánsághi, Száva; Golenár, Tünde; Madesh, Muniswamy et al. (2014) Isoform- and species-specific control of inositol 1,4,5-trisphosphate (IP3) receptors by reactive oxygen species. J Biol Chem 289:8170-81
Bhanumathy, Cunnigaiper; da Fonseca, Paula C A; Morris, Edward P et al. (2012) Identification of functionally critical residues in the channel domain of inositol trisphosphate receptors. J Biol Chem 287:43674-84
Anyatonwu, Georgia; Khan, M Tariq; Schug, Zachary T et al. (2010) Calcium-dependent conformational changes in inositol trisphosphate receptors. J Biol Chem 285:25085-93
Hawkins, Brian J; Irrinki, Krishna M; Mallilankaraman, Karthik et al. (2010) S-glutathionylation activates STIM1 and alters mitochondrial homeostasis. J Cell Biol 190:391-405
Anyatonwu, Georgia; Joseph, Suresh K (2009) Surface accessibility and conformational changes in the N-terminal domain of type I inositol trisphosphate receptors: studies using cysteine substitution mutagenesis. J Biol Chem 284:8093-102
Wagner 2nd, Larry E; Joseph, Suresh K; Yule, David I (2008) Regulation of single inositol 1,4,5-trisphosphate receptor channel activity by protein kinase A phosphorylation. J Physiol 586:3577-96
Schug, Zachary T; da Fonseca, Paula C A; Bhanumathy, Cunnigaiper D et al. (2008) Molecular characterization of the inositol 1,4,5-trisphosphate receptor pore-forming segment. J Biol Chem 283:2939-48
Khan, M Tariq; Bhanumathy, Cunnigaiper D; Schug, Zachary T et al. (2007) Role of inositol 1,4,5-trisphosphate receptors in apoptosis in DT40 lymphocytes. J Biol Chem 282:32983-90
Joseph, Suresh K; Hajnoczky, Gyorgy (2007) IP3 receptors in cell survival and apoptosis: Ca2+ release and beyond. Apoptosis 12:951-68
Khan, M Tariq; Wagner 2nd, Larry; Yule, David I et al. (2006) Akt kinase phosphorylation of inositol 1,4,5-trisphosphate receptors. J Biol Chem 281:3731-7

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