Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK035170-08S1
Application #
3233433
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1991-11-21
Project End
1994-06-30
Budget Start
1993-01-30
Budget End
1994-06-30
Support Year
8
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Missouri-Columbia
Department
Type
Schools of Medicine
DUNS #
112205955
City
Columbia
State
MO
Country
United States
Zip Code
65211
Shukla, S D (1996) Tyrosine kinase activation by PAF leads to downstream gene expression. Adv Exp Med Biol 416:153-5
James-Kracke, M R; Sexe, R B; Shukla, S D (1994) Picomolar platelet-activating factor mobilizes Ca to change platelet shape without activating phospholipase C or protein kinase C;simultaneous fluorometric measurement of intracellular free Ca concentration and aggregation. J Pharmacol Exp Ther 271:824-31
Dhar, A; Shukla, S D (1994) Electrotransjection of pp60v-src monoclonal antibody inhibits activation of phospholipase C in platelets. A new mechanism for platelet-activating factor responses. J Biol Chem 269:9123-7
Zhu, C Y; Shukla, S D (1993) Increased tyrosine kinase activity in pp60c-src immunoprecipitate from platelet activating factor stimulated human platelets: in vitro phosphorylation of a synthetic peptide. Life Sci 53:175-83
Dhar, A; Shukla, S D (1993) Tyrosine kinases in platelet signalling. Br J Haematol 84:1-7
Thurston Jr, A W; Rhee, S G; Shukla, S D (1993) Role of guanine nucleotide-binding protein and tyrosine kinase in platelet-activating factor activation of phospholipase C in A431 cells: proposal for dual mechanisms. J Pharmacol Exp Ther 266:1106-12
Shukla, S D; Paul, A; Klachko, D M (1992) Hypersensitivity of diabetic human platelets to platelet activating factor. Thromb Res 66:239-46
Shukla, S D (1992) Platelet-activating factor receptor and signal transduction mechanisms. FASEB J 6:2296-301
Shukla, S D (1991) Inositol phospholipid turnover in PAF transmembrane signalling. Lipids 26:1028-33
Shukla, S D; Halenda, S P (1991) Phospholipase D in cell signalling and its relationship to phospholipase C. Life Sci 48:851-66

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