Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
7R01DK035317-07
Application #
3233611
Study Section
Oral Biology and Medicine Subcommittee 1 (OBM)
Project Start
1986-09-17
Project End
1995-03-31
Budget Start
1993-01-01
Budget End
1993-03-31
Support Year
7
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Dentistry
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Xiao, G; Cui, Y; Ducy, P et al. (1997) Ascorbic acid-dependent activation of the osteocalcin promoter in MC3T3-E1 preosteoblasts: requirement for collagen matrix synthesis and the presence of an intact OSE2 sequence. Mol Endocrinol 11:1103-13
McCauley, L K; Koh, A J; Beecher, C A et al. (1996) PTH/PTHrP receptor is temporally regulated during osteoblast differentiation and is associated with collagen synthesis. J Cell Biochem 61:638-47
Winnard, R G; Gerstenfeld, L C; Toma, C D et al. (1995) Fibronectin gene expression, synthesis and accumulation during in vitro differentiation of chicken osteoblasts. J Bone Miner Res 10:1969-77
Franceschi, R T; Wilson, J X; Dixon, S J (1995) Requirement for Na(+)-dependent ascorbic acid transport in osteoblast function. Am J Physiol 268:C1430-9
McCauley, L K; Koh, A J; Beecher, C A et al. (1995) Effects of differentiation and transforming growth factor beta 1 on PTH/PTHrP receptor mRNA levels in MC3T3-E1 cells. J Bone Miner Res 10:1243-55
Marsh, M E; Munne, A M; Vogel, J J et al. (1995) Mineralization of bone-like extracellular matrix in the absence of functional osteoblasts. J Bone Miner Res 10:1635-43
Franceschi, R T; Iyer, B S; Cui, Y (1994) Effects of ascorbic acid on collagen matrix formation and osteoblast differentiation in murine MC3T3-E1 cells. J Bone Miner Res 9:843-54
Franceschi, R T; Iyer, B S (1992) Relationship between collagen synthesis and expression of the osteoblast phenotype in MC3T3-E1 cells. J Bone Miner Res 7:235-46
Giuliano, A R; Franceschi, R T; Wood, R J (1991) Characterization of the vitamin D receptor from the Caco-2 human colon carcinoma cell line: effect of cellular differentiation. Arch Biochem Biophys 285:261-9
Franceschi, R T; Young, J (1990) Regulation of alkaline phosphatase by 1,25-dihydroxyvitamin D3 and ascorbic acid in bone-derived cells. J Bone Miner Res 5:1157-67

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