Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK035652-12
Application #
2139616
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1984-12-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Tufts University
Department
Physiology
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02111
Cullinane, Andrew R; Straatman-Iwanowska, Anna; Zaucker, Andreas et al. (2010) Mutations in VIPAR cause an arthrogryposis, renal dysfunction and cholestasis syndrome phenotype with defects in epithelial polarization. Nat Genet 42:303-12
Kagawa, Tatehiro; Watanabe, Norihito; Mochizuki, Kaori et al. (2008) Phenotypic differences in PFIC2 and BRIC2 correlate with protein stability of mutant Bsep and impaired taurocholate secretion in MDCK II cells. Am J Physiol Gastrointest Liver Physiol 294:G58-67
Mochizuki, Kaori; Kagawa, Tatehiro; Numari, Asano et al. (2007) Two N-linked glycans are required to maintain the transport activity of the bile salt export pump (ABCB11) in MDCK II cells. Am J Physiol Gastrointest Liver Physiol 292:G818-28
Wakabayashi, Yoshiyuki; Kipp, Helmut; Arias, Irwin M (2006) Transporters on demand: intracellular reservoirs and cycling of bile canalicular ABC transporters. J Biol Chem 281:27669-73
Wakabayashi, Yoshiyuki; Dutt, Parmesh; Lippincott-Schwartz, Jennifer et al. (2005) Rab11a and myosin Vb are required for bile canalicular formation in WIF-B9 cells. Proc Natl Acad Sci U S A 102:15087-92
Chan, Wayne; Calderon, German; Swift, Amy L et al. (2005) Myosin II regulatory light chain is required for trafficking of bile salt export protein to the apical membrane in Madin-Darby canine kidney cells. J Biol Chem 280:23741-7
Ortiz, Daniel F; Moseley, James; Calderon, German et al. (2004) Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells. J Biol Chem 279:32761-70
Wakabayashi, Yoshiyuki; Lippincott-Schwartz, Jennifer; Arias, Irwin M (2004) Intracellular trafficking of bile salt export pump (ABCB11) in polarized hepatic cells: constitutive cycling between the canalicular membrane and rab11-positive endosomes. Mol Biol Cell 15:3485-96
Misra, Suniti; Varticovski, Lyuba; Arias, Irwin M (2003) Mechanisms by which cAMP increases bile acid secretion in rat liver and canalicular membrane vesicles. Am J Physiol Gastrointest Liver Physiol 285:G316-24
Kipp, Helmut; Arias, Irwin M (2002) Trafficking of canalicular ABC transporters in hepatocytes. Annu Rev Physiol 64:595-608

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