Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK036024-12
Application #
2139700
Study Section
Experimental Immunology Study Section (EI)
Project Start
1989-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
660735098
City
Worcester
State
MA
Country
United States
Zip Code
01655
Mordes, John P; Cort, Laura; Norowski, Elaine et al. (2009) Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus. Mamm Genome 20:162-9
Zipris, Danny; Lien, Egil; Nair, Anjali et al. (2007) TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat. J Immunol 178:693-701
Blankenhorn, Elizabeth P; Descipio, Cheryl; Rodemich, Lucy et al. (2007) Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVbeta4 as a candidate gene. Ann N Y Acad Sci 1103:128-31
Morrison, Alan R; Moss, Joel; Stevens, Linda A et al. (2006) ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose). J Biol Chem 281:33363-72
Beaudette-Zlatanova, B C; Whalen, B; Zipris, D et al. (2006) Costimulation and autoimmune diabetes in BB rats. Am J Transplant 6:894-902
Hillebrands, Jan-Luuk; Whalen, Barbara; Visser, Jeroen T J et al. (2006) A regulatory CD4+ T cell subset in the BB rat model of autoimmune diabetes expresses neither CD25 nor Foxp3. J Immunol 177:7820-32
Zipris, Danny; Lien, Egil; Xie, Jenny X et al. (2005) TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats. J Immunol 174:131-42
Todd, Derrick J; Forsberg, Eric M; Greiner, Dale L et al. (2004) Deficiencies in gut NK cell number and function precede diabetes onset in BB rats. J Immunol 172:5356-62
Hornum, Lars; DeScipio, Cheryl; Markholst, Helle et al. (2004) Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6. Mamm Genome 15:53-61
Mordes, John P; Bortell, Rita; Blankenhorn, Elizabeth P et al. (2004) Rat models of type 1 diabetes: genetics, environment, and autoimmunity. ILAR J 45:278-91

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