Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK036149-12
Application #
2139741
Study Section
Pathology A Study Section (PTHA)
Project Start
1985-02-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Iwata, Yasunori; Boström, Elisabeth A; Menke, Julia et al. (2012) Aberrant macrophages mediate defective kidney repair that triggers nephritis in lupus-susceptible mice. J Immunol 188:4568-80
Menke, Julia; Kriegsmann, Jörg; Schimanski, Carl Christoph et al. (2012) Autocrine CSF-1 and CSF-1 receptor coexpression promotes renal cell carcinoma growth. Cancer Res 72:187-200
Menke, Julia; Iwata, Yasunori; Rabacal, Whitney A et al. (2011) Distinct roles of CSF-1 isoforms in lupus nephritis. J Am Soc Nephrol 22:1821-33
Menke, Julia; Bork, Tillmann; Kutska, Birte et al. (2011) Targeting transcription factor Stat4 uncovers a role for interleukin-18 in the pathogenesis of severe lupus nephritis in mice. Kidney Int 79:452-63
Menke, Julia; Rabacal, Whitney A; Byrne, Katelyn T et al. (2009) Circulating CSF-1 promotes monocyte and macrophage phenotypes that enhance lupus nephritis. J Am Soc Nephrol 20:2581-92
Menke, Julia; Iwata, Yasunori; Rabacal, Whitney A et al. (2009) CSF-1 signals directly to renal tubular epithelial cells to mediate repair in mice. J Clin Invest 119:2330-42
Menke, Julia; Zeller, Geraldine C; Kikawada, Eriya et al. (2008) CXCL9, but not CXCL10, promotes CXCR3-dependent immune-mediated kidney disease. J Am Soc Nephrol 19:1177-89
Kelley, Vicki Rubin (2007) Leukocyte-renal epithelial cell interactions regulate lupus nephritis. Semin Nephrol 27:59-68
Zeller, Geraldine C; Hirahashi, Junichi; Schwarting, Andreas et al. (2006) Inducible co-stimulator null MRL-Faslpr mice: uncoupling of autoantibodies and T cell responses in lupus. J Am Soc Nephrol 17:122-30
Schwarting, Andreas; Paul, Kathrin; Tschirner, Stefan et al. (2005) Interferon-beta: a therapeutic for autoimmune lupus in MRL-Faslpr mice. J Am Soc Nephrol 16:3264-72

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