Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK036256-20
Application #
6691082
Study Section
Endocrinology Study Section (END)
Program Officer
Margolis, Ronald N
Project Start
1985-01-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
20
Fiscal Year
2004
Total Cost
$406,550
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Luongo, Cristina; Martin, Cecilia; Vella, Kristen et al. (2015) The selective loss of the type 2 iodothyronine deiodinase in mouse thyrotrophs increases basal TSH but blunts the thyrotropin response to hypothyroidism. Endocrinology 156:745-54
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Zhu, Bo; Shrivastava, Ashutosh; Luongo, Cristina et al. (2012) Catalysis leads to posttranslational inactivation of the type 1 deiodinase and alters its conformation. J Endocrinol 214:87-94
Marsili, Alessandro; Sanchez, Edith; Singru, Praful et al. (2011) Thyroxine-induced expression of pyroglutamyl peptidase II and inhibition of TSH release precedes suppression of TRH mRNA and requires type 2 deiodinase. J Endocrinol 211:73-8
Wajner, Simone Magagnin; Goemann, Iuri Martin; Bueno, Ana Laura et al. (2011) IL-6 promotes nonthyroidal illness syndrome by blocking thyroxine activation while promoting thyroid hormone inactivation in human cells. J Clin Invest 121:1834-45
Roh, Michael H; Jo, Vickie Y; Stelow, Edward B et al. (2011) The predictive value of the fine-needle aspiration diagnosis ""suspicious for a follicular neoplasm, hurthle cell type"" in patients with hashimoto thyroiditis. Am J Clin Pathol 135:139-45
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