Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK036803-10
Application #
2139875
Study Section
General Medicine B Study Section (GMB)
Project Start
1985-07-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Garzon-Muvdi, Tomas; Pacheco-Alvarez, Diana; Gagnon, Kenneth B E et al. (2007) WNK4 kinase is a negative regulator of K+-Cl- cotransporters. Am J Physiol Renal Physiol 292:F1197-207
de Los Heros, Paola; Kahle, Kristopher T; Rinehart, Jesse et al. (2006) WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway. Proc Natl Acad Sci U S A 103:1976-81
Paredes, Anahi; Plata, Consuelo; Rivera, Manuel et al. (2006) Activity of the renal Na+-K+-2Cl- cotransporter is reduced by mutagenesis of N-glycosylation sites: role for protein surface charge in Cl- transport. Am J Physiol Renal Physiol 290:F1094-102
Gamba, Gerardo (2005) Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension. Am J Physiol Renal Physiol 288:F245-52
Rinehart, Jesse; Kahle, Kristopher T; de Los Heros, Paola et al. (2005) WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis. Proc Natl Acad Sci U S A 102:16777-82
Mercado, Adriana; Mount, David B; Gamba, Gerardo (2004) Electroneutral cation-chloride cotransporters in the central nervous system. Neurochem Res 29:17-25
Hebert, Steven C; Mount, David B; Gamba, Gerardo (2004) Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family. Pflugers Arch 447:580-93
Gamba, Gerardo; Bobadilla, Norma A (2004) Molecular physiology of the renal Na(+)-Cl- and Na(+)-K(+)-2Cl- cotransporters. Adv Exp Med Biol 559:55-65
Wilson, Frederick H; Kahle, Kristopher T; Sabath, Ernesto et al. (2003) Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Natl Acad Sci U S A 100:680-4
Meade, Patricia; Hoover, Robert S; Plata, Consuelo et al. (2003) cAMP-dependent activation of the renal-specific Na+-K+-2Cl- cotransporter is mediated by regulation of cotransporter trafficking. Am J Physiol Renal Physiol 284:F1145-54

Showing the most recent 10 out of 34 publications