Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK037219-10
Application #
2140009
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1991-07-01
Project End
1999-11-30
Budget Start
1996-02-01
Budget End
1996-11-30
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Medical University of South Carolina
Department
Pharmacology
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425

  Publications

Kilpatrick, Eric L; Hildebrandt, John D (2007) Sequence dependence and differential expression of Ggamma5 subunit isoforms of the heterotrimeric G proteins variably processed after prenylation in mammalian cells. J Biol Chem 282:14038-47
Yang, Wanling; Hildebrandt, John D (2006) Genomic analysis of G protein gamma subunits in human and mouse - the relationship between conserved gene structure and G protein betagamma dimer formation. Cell Signal 18:194-201
Cook, Lana A; Schey, Kevin L; Wilcox, Michael D et al. (2006) Proteomic analysis of bovine brain G protein gamma subunit processing heterogeneity. Mol Cell Proteomics 5:671-85
Wells, Christopher A; Dingus, Jane; Hildebrandt, John D (2006) Role of the chaperonin CCT/TRiC complex in G protein betagamma-dimer assembly. J Biol Chem 281:20221-32
Dingus, Jane; Wells, Christopher A; Campbell, Lia et al. (2005) G Protein betagamma dimer formation: Gbeta and Ggamma differentially determine efficiency of in vitro dimer formation. Biochemistry 44:11882-90
Yang, Wanling; White, Brook; Spicer, Eleanor K et al. (2004) Complex haplotype structure of the human GNAS gene identifies a recombination hotspot centred on a single nucleotide polymorphism widely used in association studies. Pharmacogenetics 14:741-7
Cleator, John H; Ravenell, Roneka; Kurtz, David T et al. (2004) A dominant negative Galphas mutant that prevents thyroid-stimulating hormone receptor activation of cAMP production and inositol 1,4,5-trisphosphate turnover: competition by different G proteins for activation by a common receptor. J Biol Chem 279:36601-7
Ribas, Catalina; Takesono, Aya; Sato, Motohiko et al. (2002) Pertussis toxin-insensitive activation of the heterotrimeric G-proteins Gi/Go by the NG108-15 G-protein activator. J Biol Chem 277:50223-5
Cook, Lana A; Wilcox, Michael D; Dingus, Jane et al. (2002) Separation and analysis of G protein gamma subunits. Methods Enzymol 344:209-33
Ribas, Catalina; Sato, Motohiko; Hildebrandt, John D et al. (2002) Analysis of signal transfer from receptor to Go/Gi in different membrane environments and receptor-independent activators of brain G protein. Methods Enzymol 344:140-52

Showing the most recent 10 out of 35 publications