Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK037463-10
Application #
2140102
Study Section
Nutrition Study Section (NTN)
Project Start
1989-06-01
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Missouri Kansas City
Department
Biochemistry
Type
Schools of Medicine
DUNS #
800772162
City
Kansas City
State
MO
Country
United States
Zip Code
64110
Paoli, Massimo; Marles-Wright, Jon; Smith, Ann (2002) Structure-function relationships in heme-proteins. DNA Cell Biol 21:271-80
Escriba, Pablo V; Morales, P; Smith, Ann (2002) Membrane phospholipid reorganization differentially regulates metallothionein and heme oxygenase by heme-hemopexin. DNA Cell Biol 21:355-64
Shipulina, N V; Smith, A; Morgan, W T (2001) Effects of reduction and ligation of heme iron on the thermal stability of heme-hemopexin complexes. J Protein Chem 20:145-54
Rocha, E R; Smith, A; Smith, C J et al. (2001) Growth inhibition of Bacteroides fragilis by hemopexin: proteolytic degradation of hemopexin to overcome heme limitation. FEMS Microbiol Lett 199:73-8
Sung, L; Shibata, M; Eskew, J D et al. (2000) Cell-surface events for metallothionein-1 and heme oxygenase-1 regulation by the hemopexin-heme transport system. Antioxid Redox Signal 2:753-65
Shipulina, N; Smith, A; Morgan, W T (2000) Heme binding by hemopexin: evidence for multiple modes of binding and functional implications. J Protein Chem 19:239-48
Smith, A (2000) Links between cell-surface events involving redox-active copper and gene regulation in the hemopexin heme transport system. Antioxid Redox Signal 2:157-75
Vanacore, R M; Eskew, J D; Morales, P J et al. (2000) Role for copper in transient oxidation and nuclear translocation of MTF-1, but not of NF-kappa B, by the heme-hemopexin transport system. Antioxid Redox Signal 2:739-52
Eskew, J D; Vanacore, R M; Sung, L et al. (1999) Cellular protection mechanisms against extracellular heme. heme-hemopexin, but not free heme, activates the N-terminal c-jun kinase. J Biol Chem 274:638-48
Smith, A; Eskew, J D; Borza, C M et al. (1997) Role of heme-hemopexin in human T-lymphocyte proliferation. Exp Cell Res 232:246-54

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