Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK037908-07A2
Application #
2016211
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1987-01-01
Project End
2000-07-31
Budget Start
1996-09-30
Budget End
1997-07-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Cincinnati
Department
Surgery
Type
Schools of Medicine
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Alamdari, Nima; Aversa, Zaira; Castillero, Estibaliz et al. (2013) Acetylation and deacetylation--novel factors in muscle wasting. Metabolism 62:1-11
Aversa, Zaira; Alamdari, Nima; Castillero, Estibaliz et al. (2013) CaMKII activity is reduced in skeletal muscle during sepsis. J Cell Biochem 114:1294-305
Castillero, Estibaliz; Alamdari, Nima; Aversa, Zaira et al. (2013) PPAR?/? regulates glucocorticoid- and sepsis-induced FOXO1 activation and muscle wasting. PLoS One 8:e59726
Castillero, Estibaliz; Alamdari, Nima; Lecker, Stewart H et al. (2013) Suppression of atrogin-1 and MuRF1 prevents dexamethasone-induced atrophy of cultured myotubes. Metabolism 62:1495-502
Aversa, Zaira; Alamdari, Nima; Castillero, Estibaliz et al. (2012) ?-Hydroxy-?-methylbutyrate (HMB) prevents dexamethasone-induced myotube atrophy. Biochem Biophys Res Commun 423:739-43
Alamdari, Nima; Aversa, Zaira; Castillero, Estibaliz et al. (2012) Resveratrol prevents dexamethasone-induced expression of the muscle atrophy-related ubiquitin ligases atrogin-1 and MuRF1 in cultured myotubes through a SIRT1-dependent mechanism. Biochem Biophys Res Commun 417:528-33
Alamdari, Nima; Toraldo, Gianluca; Aversa, Zaira et al. (2012) Loss of muscle strength during sepsis is in part regulated by glucocorticoids and is associated with reduced muscle fiber stiffness. Am J Physiol Regul Integr Comp Physiol 303:R1090-9
Chamberlain, Wei; Gonnella, Patricia; Alamdari, Nima et al. (2012) Multiple muscle wasting-related transcription factors are acetylated in dexamethasone-treated muscle cells. Biochem Cell Biol 90:200-8
Smith, Ira J; Aversa, Zaira; Hasselgren, Per-Olof et al. (2011) Calpain activity is increased in skeletal muscle from gastric cancer patients with no or minimal weight loss. Muscle Nerve 43:410-4
Aversa, Zaira; Alamdari, Nima; Hasselgren, Per-Olof (2011) Molecules modulating gene transcription during muscle wasting in cancer, sepsis, and other critical illness. Crit Rev Clin Lab Sci 48:71-86

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