Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK038165-08
Application #
2140308
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1988-04-01
Project End
2000-02-29
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Leaf, Alexander; Kang, Jing X; Xiao, Yong-Fu (2005) Omega-3 fatty acids and ventricular arrhythmias. World Rev Nutr Diet 94:129-38
Xiao, Y-F; Sigg, D C; Leaf, A (2005) The antiarrhythmic effect of n-3 polyunsaturated fatty acids: modulation of cardiac ion channels as a potential mechanism. J Membr Biol 206:141-54
Xiao, Yong-Fu; Ke, Qingen; Wang, Sho-Ya et al. (2004) Electrophysiologic properties of lidocaine, cocaine, and n-3 fatty-acids block of cardiac Na+ channels. Eur J Pharmacol 485:31-41
Leaf, Alexander; Kang, Jing X; Xiao, Yong-Fu et al. (2003) Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils. Circulation 107:2646-52
Leaf, A; Xiao, Y-F; Kang, J X (2002) Interactions of n-3 fatty acids with ion channels in excitable tissues. Prostaglandins Leukot Essent Fatty Acids 67:113-20
Xiao, Yong-Fu; Morgan, James P; Leaf, Alexander (2002) Effects of polyunsaturated fatty acids on cardiac voltage-activated K(+) currents in adult ferret cardiomyocytes . Sheng Li Xue Bao 54:271-81
Leaf, A; Xiao, Y F (2001) The modulation of ionic currents in excitable tissues by n-3 polyunsaturated fatty acids. J Membr Biol 184:263-71
Xiao, Y F; Ke, Q; Wang, S Y et al. (2001) Point mutations in alpha-subunit of human cardiac Na+ channels alter Na+ current kinetics. Biochem Biophys Res Commun 281:45-52
Xiao, Y F; Ke, Q; Wang, S Y et al. (2001) Single point mutations affect fatty acid block of human myocardial sodium channel alpha subunit Na+ channels. Proc Natl Acad Sci U S A 98:3606-11
Leaf, A (2001) The electrophysiologic basis for the antiarrhythmic and anticonvulsant effects of n-3 polyunsaturated fatty acids: heart and brain. Lipids 36 Suppl:S107-10

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