Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK038320-11
Application #
2140467
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1986-08-15
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Emory University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Doering, C B; Danner, D J (2000) Amino acid deprivation induces translation of branched-chain alpha-ketoacid dehydrogenase kinase. Am J Physiol Cell Physiol 279:C1587-94
Doering, C B; Danner, D J (2000) Expression of murine branched-chain alpha-keto acid dehydrogenase kinase. Methods Enzymol 324:491-7
Doering, C B; Williams, I R; Danner, D J (2000) Controlled overexpression of BCKD kinase expression: metabolic engineering applied to BCAA metabolism in a mammalian system. Metab Eng 2:349-56
Danner, D J; Doering, C B (1998) Human mutations affecting branched chain alpha-ketoacid dehydrogenase. Front Biosci 3:d517-24
Sitler, T L; McKean, M C; Peinemann, F et al. (1998) Import rate of the E1beta subunit of human branched chain alpha-ketoacid dehydrogenase is a limiting factor in the amount of complex formed in the mitochondria. Biochim Biophys Acta 1404:385-92
Doering, C B; Coursey, C; Spangler, W et al. (1998) Murine branched chain alpha-ketoacid dehydrogenase kinase;cDNA cloning, tissue distribution, and temporal expression during embryonic development. Gene 212:213-9
McConnell, B B; Burkholder, B; Danner, D J (1997) Two new mutations in the human E1 beta subunit of branched chain alpha-ketoacid dehydrogenase associated with maple syrup urine disease. Biochim Biophys Acta 1361:263-71
McConnell, B B; McKean, M C; Danner, D J (1996) Influence of subunit transcript and protein levels on formation of a mitochondrial multienzyme complex. J Cell Biochem 61:118-26
Lanterman, M M; Dickinson, J R; Danner, D J (1996) Functional analysis in Saccharomyces cerevisiae of naturally occurring amino acid substitutions in human dihydrolipoamide dehydrogenase. Hum Mol Genet 5:1643-8
England, B K; Greiber, S; Mitch, W E et al. (1995) Rat muscle branched-chain ketoacid dehydrogenase activity and mRNAs increase with extracellular acidemia. Am J Physiol 268:C1395-400

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