Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK038325-10S1
Application #
655063
Study Section
Metabolism Study Section (MET)
Project Start
1985-12-01
Project End
1997-06-30
Budget Start
1995-07-01
Budget End
1997-06-30
Support Year
10
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Abebe, Tsehay; Mahadevan, Jana; Bogachus, Lindsey et al. (2017) Nrf2/antioxidant pathway mediates ? cell self-repair after damage by high-fat diet-induced oxidative stress. JCI Insight 2:
Guo, Shuangli; Dai, Chunhua; Guo, Min et al. (2013) Inactivation of specific ? cell transcription factors in type 2 diabetes. J Clin Invest 123:3305-16
Robertson, R P; Zhou, H; Slucca, M (2011) A role for zinc in pancreatic islet ýý-cell cross-talk with the ýý-cell during hypoglycaemia. Diabetes Obes Metab 13 Suppl 1:106-11
Poitout, Vincent; Robertson, R Paul (2008) Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocr Rev 29:351-66
Poitout, Vincent; Hagman, Derek; Stein, Roland et al. (2006) Regulation of the insulin gene by glucose and fatty acids. J Nutr 136:873-6
Robertson, R Paul; Tanaka, Yoshito; Takahashi, Hiroki et al. (2005) Prevention of oxidative stress by adenoviral overexpression of glutathione-related enzymes in pancreatic islets. Ann N Y Acad Sci 1043:513-20
Harmon, Jamie S; Stein, Roland; Robertson, R Paul (2005) Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells. J Biol Chem 280:11107-13
Robertson, R Paul; Harmon, Jamie; Tran, Phuong Oanh T et al. (2004) Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes 53 Suppl 1:S119-24
Takahashi, Hiroki; Tran, Phuong Oanh T; LeRoy, Eric et al. (2004) D-Glyceraldehyde causes production of intracellular peroxide in pancreatic islets, oxidative stress, and defective beta cell function via non-mitochondrial pathways. J Biol Chem 279:37316-23
Tran, Phuong Oanh T; Parker, Sarah M; LeRoy, Eric et al. (2004) Adenoviral overexpression of the glutamylcysteine ligase catalytic subunit protects pancreatic islets against oxidative stress. J Biol Chem 279:53988-93

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