Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK038354-10
Application #
2140493
Study Section
Special Emphasis Panel (NSS)
Program Officer
Laughlin, Maren R
Project Start
1986-06-01
Project End
1998-02-28
Budget Start
1996-03-01
Budget End
1998-02-28
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Biochemistry
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Pedersen, Kim B; Zhang, Pili; Doumen, Chris et al. (2007) The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions. Am J Physiol Endocrinol Metab 292:E788-801
Wu, Chaodong; Khan, Salmaan A; Peng, Li-Jen et al. (2006) Roles for fructose-2,6-bisphosphate in the control of fuel metabolism: beyond its allosteric effects on glycolytic and gluconeogenic enzymes. Adv Enzyme Regul 46:72-88
Wu, Chaodong; Khan, Salmaan A; Peng, Li-Jen et al. (2006) Perturbation of glucose flux in the liver by decreasing F26P2 levels causes hepatic insulin resistance and hyperglycemia. Am J Physiol Endocrinol Metab 291:E536-43
Wu, Chaodong; Kang, Johnthomas E; Peng, Li-Jen et al. (2005) Enhancing hepatic glycolysis reduces obesity: differential effects on lipogenesis depend on site of glycolytic modulation. Cell Metab 2:131-40
Wu, Chaodong; Okar, David A; Kang, Johnthomas et al. (2005) Reduction of hepatic glucose production as a therapeutic target in the treatment of diabetes. Curr Drug Targets Immune Endocr Metabol Disord 5:51-9
Baar, Rachel A; Dingfelder, Carlus S; Smith, Lisa A et al. (2005) Investigation of in vivo fatty acid metabolism in AFABP/aP2(-/-) mice. Am J Physiol Endocrinol Metab 288:E187-93
Wu, Chaodong; Okar, David A; Stoeckman, Angela K et al. (2004) A potential role for fructose-2,6-bisphosphate in the stimulation of hepatic glucokinase gene expression. Endocrinology 145:650-8
Okar, David A; Wu, Chaodong; Lange, Alex J (2004) Regulation of the regulatory enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Adv Enzyme Regul 44:123-54
Massa, Laura; Baltrusch, Simone; Okar, David A et al. (2004) Interaction of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) with glucokinase activates glucose phosphorylation and glucose metabolism in insulin-producing cells. Diabetes 53:1020-9
Donthi, Rajakumar V; Ye, Gang; Wu, Chaodong et al. (2004) Cardiac expression of kinase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase inhibits glycolysis, promotes hypertrophy, impairs myocyte function, and reduces insulin sensitivity. J Biol Chem 279:48085-90

Showing the most recent 10 out of 73 publications