Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK038712-08
Application #
2140630
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1987-07-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Joslin Diabetes Center
Department
Type
DUNS #
071723084
City
Boston
State
MA
Country
United States
Zip Code
02215
Kuznetsova, Alexandra; Yu, Yue; Hollister-Lock, Jennifer et al. (2016) Trimeprazine increases IRS2 in human islets and promotes pancreatic ? cell growth and function in mice. JCI Insight 1:
Copps, Kyle D; Hançer, Nancy J; Qiu, Wei et al. (2016) Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase. J Biol Chem 291:8602-17
Law, Nathan C; White, Morris F; Hunzicker-Dunn, Mary E (2016) G protein-coupled receptors (GPCRs) That Signal via Protein Kinase A (PKA) Cross-talk at Insulin Receptor Substrate 1 (IRS1) to Activate the phosphatidylinositol 3-kinase (PI3K)/AKT Pathway. J Biol Chem 291:27160-27169
Hançer, Nancy J; Qiu, Wei; Cherella, Christine et al. (2014) Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation. J Biol Chem 289:12467-84
Ryu, Jiyoon; Galan, Amanda K; Xin, Xiaoban et al. (2014) APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor. Cell Rep 7:1227-38
Herrema, Hilde; Lee, Jaemin; Zhou, Yingjiang et al. (2014) IRS1Ser³?? phosphorylation does not mediate mTORC1-induced insulin resistance. Biochem Biophys Res Commun 443:689-93
Sadagurski, Marianna; Dong, X Charlie; Myers Jr, Martin G et al. (2014) Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis. Mol Metab 3:55-63
Sadagurski, Marianna; White, Morris F (2013) Integrating metabolism and longevity through insulin and IGF1 signaling. Endocrinol Metab Clin North Am 42:127-48
Riehle, Christian; Wende, Adam R; Sena, Sandra et al. (2013) Insulin receptor substrate signaling suppresses neonatal autophagy in the heart. J Clin Invest 123:5319-33
Qi, Yajuan; Xu, Zihui; Zhu, Qinglei et al. (2013) Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38? MAPK during insulin resistance. Diabetes 62:3887-900

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