Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK040029-08
Application #
2141160
Study Section
Biochemistry Study Section (BIO)
Project Start
1989-09-01
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Physiology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Henesy, Michelle B; Britain, Andrea L; Zhu, Bing et al. (2012) Calcineurin regulates homologous desensitization of natriuretic peptide receptor-A and inhibits ANP-induced testosterone production in MA-10 cells. PLoS One 7:e41711
Francis, Sharron H; Blount, Mitsi A; Corbin, Jackie D (2011) Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions. Physiol Rev 91:651-90
Francis, Sharron H; Sekhar, Konjeti R; Ke, Hengming et al. (2011) Inhibition of cyclic nucleotide phosphodiesterases by methylxanthines and related compounds. Handb Exp Pharmacol :93-133
Francis, Sharron H (2010) The role of cGMP-dependent protein kinase in controlling cardiomyocyte cGMP. Circ Res 107:1164-6
Francis, Sharron H; Busch, Jennifer L; Corbin, Jackie D et al. (2010) cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action. Pharmacol Rev 62:525-63
Corbin, Jackie D; Zoraghi, Roya; Francis, Sharron H (2009) Allosteric-site and catalytic-site ligand effects on PDE5 functions are associated with distinct changes in physical form of the enzyme. Cell Signal 21:1768-74
Weeks 2nd, James L; Corbin, Jackie D; Francis, Sharron H (2009) Interactions between cyclic nucleotide phosphodiesterase 11 catalytic site and substrates or tadalafil and role of a critical Gln-869 hydrogen bond. J Pharmacol Exp Ther 331:133-41
Vandeput, Fabrice; Krall, Judith; Ockaili, Ramzi et al. (2009) cGMP-hydrolytic activity and its inhibition by sildenafil in normal and failing human and mouse myocardium. J Pharmacol Exp Ther 330:884-91
Liu, Yu-Ting; Matte, Suzanne L; Corbin, Jackie D et al. (2009) Probing the catalytic sites and activation mechanism of photoreceptor phosphodiesterase using radiolabeled phosphodiesterase inhibitors. J Biol Chem 284:31541-7
Steiner, Jennifer A; Carneiro, Ana Marin D; Wright, Jane et al. (2009) cGMP-dependent protein kinase Ialpha associates with the antidepressant-sensitive serotonin transporter and dictates rapid modulation of serotonin uptake. Mol Brain 2:26

Showing the most recent 10 out of 72 publications