Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK040247-07
Application #
2141248
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1989-05-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1998-06-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Physiology
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Kechele, Daniel O; Blue, R Eric; Zwarycz, Bailey et al. (2017) Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation. J Clin Invest 127:593-607
Poindexter, Shenika V; Reddy, Vishruth K; Mittal, Mukul K et al. (2015) Transcriptional corepressor MTG16 regulates small intestinal crypt proliferation and crypt regeneration after radiation-induced injury. Am J Physiol Gastrointest Liver Physiol 308:G562-71
Santoro, M Agostina; Blue, R Eric; Andres, Sarah F et al. (2015) Obesity and intestinal epithelial deletion of the insulin receptor, but not the IGF 1 receptor, affect radiation-induced apoptosis in colon. Am J Physiol Gastrointest Liver Physiol 309:G578-89
Andres, Sarah F; Santoro, M Agostina; Mah, Amanda T et al. (2015) Deletion of intestinal epithelial insulin receptor attenuates high-fat diet-induced elevations in cholesterol and stem, enteroendocrine, and Paneth cell mRNAs. Am J Physiol Gastrointest Liver Physiol 308:G100-11
Van Landeghem, Laurianne; Santoro, M Agostina; Mah, Amanda T et al. (2015) IGF1 stimulates crypt expansion via differential activation of 2 intestinal stem cell populations. FASEB J 29:2828-42
Mah, Amanda T; Van Landeghem, Laurianne; Gavin, Hannah E et al. (2014) Impact of diet-induced obesity on intestinal stem cells: hyperproliferation but impaired intrinsic function that requires insulin/IGF1. Endocrinology 155:3302-14
Santoro, M Agostina; Andres, Sarah F; Galanko, Joseph A et al. (2014) Reduced insulin-like growth factor I receptor and altered insulin receptor isoform mRNAs in normal mucosa predict colorectal adenoma risk. Cancer Epidemiol Biomarkers Prev 23:2093-100
Andres, Sarah F; Simmons, James G; Mah, Amanda T et al. (2013) Insulin receptor isoform switching in intestinal stem cells, progenitors, differentiated lineages and tumors: evidence that IR-B limits proliferation. J Cell Sci 126:5645-56
Hamilton, Kathryn E; Tétreault, Marie-Pier; Lund, P Kay (2013) Opportunities and challenges for women PhD investigators in gastrointestinal research. Gastroenterology 145:266-71
Van Landeghem, Laurianne; Santoro, M Agostina; Krebs, Adrienne E et al. (2012) Activation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation. Am J Physiol Gastrointest Liver Physiol 302:G1111-32

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