To characterize and define the role of MEG3, a pituitary derived gene, to increase the understating of its role in human pituitary tumors which represent up to 40% of all diagnosed pituitary neoplasms. These tumors commonly lead to visual loss and many other severe neurologic and endocrine deficits.

Public Health Relevance

Human pituitary tumors of a gonadotroph cell origin represent up to 40% of all diagnosed pituitary neoplasms, can cause visual loss and other neurologic deficits, and have no established medical treatment. We have found a pituitary-derived gene, MEG3, which may function as a tumor suppressor. Investigation of the function of this gene will provide important information regarding the pathogenesis of human pituitary adenomas, and, potentially, other human tumors.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Research Project (R01)
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Molecular and Cellular Endocrinology Study Section (MCE)
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Malozowski, Saul N
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Massachusetts General Hospital
United States
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