To characterize and define the role of MEG3, a pituitary derived gene, to increase the understating of its role in human pituitary tumors which represent up to 40% of all diagnosed pituitary neoplasms. These tumors commonly lead to visual loss and many other severe neurologic and endocrine deficits.
Human pituitary tumors of a gonadotroph cell origin represent up to 40% of all diagnosed pituitary neoplasms, can cause visual loss and other neurologic deficits, and have no established medical treatment. We have found a pituitary-derived gene, MEG3, which may function as a tumor suppressor. Investigation of the function of this gene will provide important information regarding the pathogenesis of human pituitary adenomas, and, potentially, other human tumors.
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|Zhou, Yunli; Zhang, Xun; Klibanski, Anne (2014) Genetic and epigenetic mutations of tumor suppressive genes in sporadic pituitary adenoma. Mol Cell Endocrinol 386:16-33|
|Zhou, Yunli; Zhang, Xun; Klibanski, Anne (2012) MEG3 noncoding RNA: a tumor suppressor. J Mol Endocrinol 48:R45-53|
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|Zhang, Xun; Gejman, Roger; Mahta, Ali et al. (2010) Maternally expressed gene 3, an imprinted noncoding RNA gene, is associated with meningioma pathogenesis and progression. Cancer Res 70:2350-8|
|Zhang, Xun; Rice, Kimberley; Wang, Yingying et al. (2010) Maternally expressed gene 3 (MEG3) noncoding ribonucleic acid: isoform structure, expression, and functions. Endocrinology 151:939-47|
|Zhang, Xun; Zhou, Yunli; Klibanski, Anne (2010) Isolation and characterization of novel pituitary tumor related genes: a cDNA representational difference approach. Mol Cell Endocrinol 326:40-7|
|Zhou, Yunli; Cheunsuchon, Pornsuk; Nakayama, Yuki et al. (2010) Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene. Development 137:2643-52|
|Gejman, Roger; Batista, Dalia L; Zhong, Ying et al. (2008) Selective loss of MEG3 expression and intergenic differentially methylated region hypermethylation in the MEG3/DLK1 locus in human clinically nonfunctioning pituitary adenomas. J Clin Endocrinol Metab 93:4119-25|
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