Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK041842-02
Application #
3242755
Study Section
Endocrinology Study Section (END)
Project Start
1989-08-01
Project End
1992-07-31
Budget Start
1990-08-01
Budget End
1991-07-31
Support Year
2
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Lou, Xiaohua; Toresson, Gudrun; Benod, Cindy et al. (2014) Structure of the retinoid X receptor ?-liver X receptor ? (RXR?-LXR?) heterodimer on DNA. Nat Struct Mol Biol 21:277-81
Figueira, A C M; Saidemberg, D M; Souza, P C T et al. (2011) Analysis of agonist and antagonist effects on thyroid hormone receptor conformation by hydrogen/deuterium exchange. Mol Endocrinol 25:15-31
Cunha Lima, Suzana T; Nguyen, Ngoc-Ha; Togashi, Marie et al. (2009) Differential effects of TR ligands on hormone dissociation rates: evidence for multiple ligand entry/exit pathways. J Steroid Biochem Mol Biol 117:125-31
Jouravel, Natalia; Sablin, Elena; Togashi, Marie et al. (2009) Molecular basis for dimer formation of TRbeta variant D355R. Proteins 75:111-7
Figueira, Ana Carolina Migliorini; Neto, Mario de Oliveira; Bernardes, Amanda et al. (2007) Low-resolution structures of thyroid hormone receptor dimers and tetramers in solution. Biochemistry 46:1273-83
Nguyen, Ngoc-Ha; Apriletti, James W; Baxter, John D et al. (2005) Hammett analysis of selective thyroid hormone receptor modulators reveals structural and electronic requirements for hormone antagonists. J Am Chem Soc 127:4599-608
Togashi, Marie; Borngraeber, Sabine; Sandler, Ben et al. (2005) Conformational adaptation of nuclear receptor ligand binding domains to agonists: potential for novel approaches to ligand design. J Steroid Biochem Mol Biol 93:127-37
Gloss, Bernd; Giannocco, Gisele; Swanson, Eric A et al. (2005) Different configurations of specific thyroid hormone response elements mediate opposite effects of thyroid hormone and GC-1 on gene expression. Endocrinology 146:4926-33
Nunes, F M; Aparicio, R; Santos, M A M et al. (2004) Crystallization and preliminary X-ray diffraction studies of isoform alpha1 of the human thyroid hormone receptor ligand-binding domain. Acta Crystallogr D Biol Crystallogr 60:1867-70
Sandler, Ben; Webb, Paul; Apriletti, James W et al. (2004) Thyroxine-thyroid hormone receptor interactions. J Biol Chem 279:55801-8

Showing the most recent 10 out of 33 publications