Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK042182-07
Application #
2142170
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1990-01-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Connecticut
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Farmington
State
CT
Country
United States
Zip Code
06030
Smolic, Martina; Wu, Catherine H; Madadi, Shilpa et al. (2012) Pharmacogenetic selection of transplanted human hepatocytes in immunocompetent rats. J Dig Dis 13:579-87
Smolic, Robert; Smolic, Martina; Andorfer, John H et al. (2010) Inhibition of hepatitis C virus replication by single-stranded RNA structural mimics. World J Gastroenterol 16:2100-8
Volarevic, Martina; Wu, Catherine H; Smolic, Robert et al. (2007) A novel G418 conjugate results in targeted selection of genetically protected hepatocytes without bystander toxicity. Bioconjug Chem 18:1965-71
Smith, R M; Smolic, R; Volarevic, M et al. (2007) Positional effects and strand preference of RNA interference against hepatitis C virus target sequences. J Viral Hepat 14:194-212
Konishi, Masayoshi; Wu, Catherine H; Kaito, Masahiko et al. (2006) siRNA-resistance in treated HCV replicon cells is correlated with the development of specific HCV mutations. J Viral Hepat 13:756-61
Virovic, Lucija; Wu, Catherine H; Konishi, Masayoshi et al. (2005) Novel delivery methods for treatment of viral hepatitis: an update. Expert Opin Drug Deliv 2:707-17
Wu, George Y; Konishi, Masayoshi; Walton, Cherie M et al. (2005) A novel immunocompetent rat model of HCV infection and hepatitis. Gastroenterology 128:1416-23
Smith, R M; Wu, G Y (2004) Secondary structure and hybridization accessibility of the hepatitis C virus negative strand RNA 5'-terminus. J Viral Hepat 11:115-23
Fukuma, Toshiko; Walton, Cherie M; Wu, Catherine H et al. (2003) Conjugation of an antisense oligodeoxynucleotide to ribonuclease h results in sequence-specific cleavage and intracellular inhibition of HCV gene expression. Bioconjug Chem 14:295-301
Konishi, Masayoshi; Wu, Catherine H; Wu, George Y (2003) Inhibition of HBV replication by siRNA in a stable HBV-producing cell line. Hepatology 38:842-50

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