Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK043051-05
Application #
2142729
Study Section
Metabolism Study Section (MET)
Project Start
1992-02-01
Project End
1997-01-31
Budget Start
1996-02-27
Budget End
1997-01-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215
Hammarstedt, Ann; Syed, Ismail; Vijayakumar, Archana et al. (2018) Adipose tissue dysfunction is associated with low levels of the novel Palmitic Acid Hydroxystearic Acids. Sci Rep 8:15757
Kolar, Matthew J; Nelson, Andrew T; Chang, Tina et al. (2018) Faster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements. Anal Chem 90:5358-5365
Syed, Ismail; Lee, Jennifer; Moraes-Vieira, Pedro M et al. (2018) Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis. Cell Metab 27:419-427.e4
Nelson, Andrew T; Kolar, Matthew J; Chu, Qian et al. (2017) Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation. J Am Chem Soc 139:4943-4947
Vijayakumar, Archana; Aryal, Pratik; Wen, Jennifer et al. (2017) Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport. Cell Rep 21:1021-1035
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Reno, Candace M; Puente, Erwin C; Sheng, Zhenyu et al. (2017) Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation. Diabetes 66:587-597
Lee, Jennifer; Moraes-Vieira, Pedro M; Castoldi, Angela et al. (2016) Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses. J Biol Chem 291:22207-22217
Zhang, Tejia; Chen, Shili; Syed, Ismail et al. (2016) A LC-MS-based workflow for measurement of branched fatty acid esters of hydroxy fatty acids. Nat Protoc 11:747-63
Kolar, Matthew J; Kamat, Siddhesh S; Parsons, William H et al. (2016) Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. Biochemistry 55:4636-41

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