Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK043396-05
Application #
2142985
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1991-08-01
Project End
1996-11-30
Budget Start
1995-08-01
Budget End
1996-11-30
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Thomas Jefferson University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107

  Publications

Tang, Tao; Thompson, Joel C; Wilson, Patricia G et al. (2013) Decreased body fat, elevated plasma transforming growth factor-? levels, and impaired BMP4-like signaling in biglycan-deficient mice. Connect Tissue Res 54:5-13
Wu, Xiangdong; Chen, Keyang; Williams, Kevin Jon (2012) The role of pathway-selective insulin resistance and responsiveness in diabetic dyslipoproteinemia. Curr Opin Lipidol 23:334-44
Wu, Xiangdong; Williams, Kevin Jon (2012) NOX4 pathway as a source of selective insulin resistance and responsiveness. Arterioscler Thromb Vasc Biol 32:1236-45
Chen, Keyang; Liu, Ming-Lin; Schaffer, Lana et al. (2010) Type 2 diabetes in mice induces hepatic overexpression of sulfatase 2, a novel factor that suppresses uptake of remnant lipoproteins. Hepatology 52:1957-67
Williams, Kevin Jon; Chen, Keyang (2010) Recent insights into factors affecting remnant lipoprotein uptake. Curr Opin Lipidol 21:218-28
Goldstein, Barry J (2008) Inflammatory signaling: another drug target to improve glycemic control in type 2 diabetes. Clin Transl Sci 1:43-4
Hu, Taishan; Ramachandrarao, Satish P; Siva, Senthuran et al. (2005) Reactive oxygen species production via NADPH oxidase mediates TGF-beta-induced cytoskeletal alterations in endothelial cells. Am J Physiol Renal Physiol 289:F816-25
Goldstein, Barry J; Mahadev, Kalyankar; Kalyankar, Mahadev et al. (2005) Redox paradox: insulin action is facilitated by insulin-stimulated reactive oxygen species with multiple potential signaling targets. Diabetes 54:311-21
Wu, Xiangdong; Zhu, Li; Zilbering, Assaf et al. (2005) Hyperglycemia potentiates H(2)O(2) production in adipocytes and enhances insulin signal transduction: potential role for oxidative inhibition of thiol-sensitive protein-tyrosine phosphatases. Antioxid Redox Signal 7:526-37
Goldstein, Barry J; Mahadev, Kalyankar; Wu, Xiangdong et al. (2005) Role of insulin-induced reactive oxygen species in the insulin signaling pathway. Antioxid Redox Signal 7:1021-31

Showing the most recent 10 out of 43 publications